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脂毒性在非酒精性脂肪性肝病发生发展中的作用
DOI: 10.3969/j.issn.1001-5256.2021.02.045
作者贡献声明：张丽慧负责查询文献，撰写论文；刘鸣昊参与修改论文；赵文霞负责指导撰写论文，修改论文并最后定稿。
Role of lipotoxicity in the development and progression of nonalcoholic fatty liver disease
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摘要: 非酒精性脂肪性肝病(NAFLD)目前是体检时肝脏生化学指标异常的首要原因，但其发生发展的机制仍不十分明确，尚缺乏有效的治疗方法。简述了脂毒性通过触发肝脏内质网应激、细胞死亡、炎症三种病理反应驱动NAFLD向非酒精性脂肪性肝炎、肝硬化的发生及转化，认为脂毒性是促进NAFLD向炎症、纤维化发展的重要因素，为NAFLD的防治提供一种新的途径。Abstract: Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of abnormal liver biochemical parameters, but the mechanism of its development and progression remains unclear and there is a lack of effective treatment methods. This article reviews that lipotoxicity drives the transformation of NAFLD to nonalcoholic steatohepatitis and liver cirrhosis by triggering the three pathological responses in the liver, i.e., endoplasmic reticulum stress, cell death, and inflammation. It is believed that lipotoxicity is an important factor that promotes the progression of NAFLD to inflammation and fibrosis, which provides a new method for the prevention and treatment of NAFLD.
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