长链非编码RNA对肝纤维化的调控作用

卢能源; 钟芳菲; 邓青梅; 杨研琪; 郑洋; 赵铁建; 梁天坚

doi:10.3969/j.issn.1001-5256.2020.12.035

长链非编码RNA对肝纤维化的调控作用

DOI: 10.3969/j.issn.1001-5256.2020.12.035

1. 广西中医药大学赛恩斯新医药学院
2. 广西中医药大学基础医学院生理教研室

基金项目:

国家自然科学基金（81460682,81660705,81960751）；广西中青年教师科研基础能力提升项目（2020KY59009）；广西中医药大学赛恩斯新医药学院大学生创新创业训练项目（国家级）（202013643009）;广西中医药大学赛恩斯新医药学院大学生创新创业训练项目（国家级）（202013643014）;广西中医药大学赛恩斯新医药学院大学生创新创业训练项目（自治区级）（202013643027）;广西中医药大学赛恩斯新医药学院大学生创新创业训练项目（自治区级）（202013643032）；

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中图分类号: R575.2
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出版历程
- 收稿日期: 2020-06-18
- 出版日期: 2020-12-20

Regulatory effect of long non-coding RNAs on liver fibrosis

Faculty of Chinese Medicine Science,School of Basic Medical Sciences,Guangxi University of Chinese Medicine
Department of Physiology,School of Basic Medical Sciences,Guangxi University of Chinese Medicine

Research funding:

摘要

摘要:
长链非编码RNA（lncRNA）在肝纤维化的发展过程当中发挥着重要的调控作用。简述了lncRNA的定义、分类及生物学功能,归纳了近些年来关于lncRNA通过充当竞争性内源RNA而对肝纤维化发挥调控作用的相关报道,其中不乏在肝纤维化小鼠或肝纤维化患者肝组织中表达下调的母系表达基因3、生长停滞特异性转录本5、长基因间非编码RNA-p21和表达上调的肺腺癌相关转录本1、转化生长因子β激活的lncRNA、浆细胞瘤变型异位子1、同源盒转录反义RNA、长链非编码RNA-H19以及小核RNA宿主基因7。以期为肝纤维化诊断、治疗靶标的筛选和临床逆转肝纤维化方案的形成提供参考。
- RNA,长链非编码 /
- 肝硬化 /
- 肝星状细胞 /
- 竞争性内源RNA
Abstract:
A large number of studies in recent years have shown that long non-coding RNAs( lncRNAs) play an important regulatory role in the progression of liver fibrosis. This article briefly describes the definition,classification,and biological functions of lncRNAs and summarizes recent reports on the regulatory role of lncRNAs in liver fibrosis by acting as competitive endogenous RNA,including downregulated maternally expressed gene 3,growth arrest-specific transcript 5,and long intergenic non-coding RNA-p21 and upregulated lung adenocarcinoma-associated transcript 1,lncRNA-activated by transforming growth factor beta,plasmacytoma variant translocation 1,homeobox transcript antisense RNA,lncRNA-H19,and small nuclear RNA host gene 7,so as to provide insights into the diagnosis of liver fibrosis,the screening of therapeutic targets,and the development of clinical treatment regimens for the reversal of liver fibrosis.
- RNA,long untranslated /
- liver cirrhosis /
- hepatic stellate cells /
- competitive endogenous RNA

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