胆汁酸在肝肠循环中的作用及中药参与其调控的相关机制

叶倩伶; 王明刚; 毛德文; 蒋海南

doi:10.3969/j.issn.1001-5256.2020.11.050

胆汁酸在肝肠循环中的作用及中药参与其调控的相关机制

DOI: 10.3969/j.issn.1001-5256.2020.11.050

1. 广西中医药大学第一临床医学院
2. 广西中医药大学第一附属医院肝病科

基金项目:

国家自然科学基金项目（81704021,81960841）；广西自然科学基金（2017GXNSFBA198200,2018GXNSFAA281047）;广西自然科学基金创新研究团队项目（2018GXNSFGA281002）；广西中医肝病临床医学研究中心（桂科AD17129001）；广西高校中青年教师基础能力提升项目（KY2016YB208）；广西中医药大学硕士研究生科研创新项目（YCSZ2020025）；

详细信息

中图分类号: R259
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出版历程
- 收稿日期: 2020-04-15
- 出版日期: 2020-11-20

Role of bile acids in enterohepatic circulation and mechanism of action of traditional Chinese medicine in regulating bile acids

The First Clinical Medical College,Guangxi University of Chinese Medicine
Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine

Research funding:

摘要

摘要:
胆汁酸在肝脏中产生,是胆固醇分解代谢的最终产物,具有广泛的生物学效应。就胆汁酸的合成、转运、代谢,及其通过肝肠循环调控肝脏细胞及免疫方面的研究进展、中医药在调控胆汁酸这一领域的研究现状作一综述,深入了解胆汁酸影响肠道菌群及肝脏功能的相关机制,拓展其调控机制的认识,探索中医药对胆汁酸调节的作用机制及途径,为从调控胆汁酸途径防治肝脏相关系统性疾病提供新思路。
- 胆汁酸类和盐类 /
- 胃肠道微生物组 /
- 中草药
Abstract:
Bile acids( BAs) are produced in the liver and are the final product of cholesterol catabolism,with a wide range of biological effects. This article reviews the research advances in the synthesis,transport,and metabolism of BAs and the role of BAs in regulating hepatocytes and immunity via enterohepatic circulation,as well as the current research on traditional Chinese medicine in the regulation of BAs,in order to further understand the mechanism of action of BAs in affecting intestinal flora and liver function,expand the knowledge of its regulatory mechanism,explore the mechanism of action of traditional Chinese medicine and related pathways in regulating BAs,and provide new ideas for the prevention and treatment of liver-related systemic diseases by regulating BAs.
- bile acids and salts /
- gastrointestinal microbiome /
- drugs,Chinese herbal

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