噬菌体在酒精性肝病治疗中的应用

马欢; 佟静; 王炳元

doi:10.3969/j.issn.1001-5256.2020.11.047

噬菌体在酒精性肝病治疗中的应用

DOI: 10.3969/j.issn.1001-5256.2020.11.047

1. 锦州医科大学附属第一医院消化内科
2. 中国医科大学附属第一医院消化内科

基金项目:

国家青年自然科学基金（8170030364）；

详细信息

中图分类号: R575.5
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- 被引次数: 0
出版历程
- 收稿日期: 2020-05-23
- 出版日期: 2020-11-20

Application of bacteriophage technique in the treatment of alcoholic liver disease

Department of Gastroenterology,The First Affiliated Hospital of Jinzhou Medical University
Department of Gastroenterology,The First Affiliated Hospital of China Medical University

Research funding:

摘要

摘要:
酒精性肝炎是一种严重的酒精相关性肝病,病死率高达40%。最近的一项研究揭示了分泌外毒素（溶细胞素）的肠道细菌粪肠球菌是导致酒精性肝炎的关键因素,可以用噬菌体消除粪肠球菌。因此利用噬菌体治疗酒精性肝炎为临床医师提供了新的治疗方案。介绍这项开创性研究的同时,还进一步介绍了有关噬菌体和溶细胞素的相关知识,为酒精性肝炎的临床研究提供理论基础。
- 肝炎,酒精性 /
- 细菌噬菌体 /
- 穿孔素 /
- 治疗学
Abstract:
Alcoholic hepatitis( AH) is a severe alcohol-associated liver disease with a mortality rate as high as 40%. A recent study reveals that the exotoxin( cytolysin)-secreting gut bacterium Enterococcus faecalis is a critical factor for AH,which can be eliminated by bacteriophages,and therefore,the use of bacteriophages for the treatment of AH provide a new treatment option for AH. This article introduces this pioneering study and the knowledge of bacteriophages and cytolysin,so as to provide a theoretical basis for the clinical research on AH.
- hepatitis,alcoholic /
- bacteriophages /
- perforin /
- therapeutics

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参考文献(21)

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