肝窦内皮细胞在非酒精性脂肪性肝病发病过程中的作用

杨婧; 高红; 赵耀伟; 王锐

doi:10.3969/j.issn.1001-5256.2020.11.046

肝窦内皮细胞在非酒精性脂肪性肝病发病过程中的作用

DOI: 10.3969/j.issn.1001-5256.2020.11.046

黑龙江中医药大学基础医学院

基金项目:

国家自然基金青年基金项目（81603418）；黑龙江省自然科学基金项目（H2016062）；

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2020-04-01
- 出版日期: 2020-11-20

Role of liver sinusoidal endothelial cells in the pathogenesis of nonalcoholic fatty liver disease

School of Basic Medical Sciences,Heilongjiang University of Chinese Medicine

Research funding:

摘要

摘要:
随着非酒精性脂肪性肝病（NAFLD）在西方发达国家和我国富裕地区的发病率逐年上升,与其相关的治疗手段也在不`断地提高,日益成为人们关注的研究热点。而肝窦内皮细胞（LSEC）作为肝脏的重要生理结构,在NAFLD的发生和发展中发挥着重要的作用。总结了LSEC在NAFLD发病过程中的作用机制,主要包括以下途径:LSEC毛细血管化在单纯性脂肪肝中发生并促进脂肪变性;同时,LSEC有助于非酒精性脂肪性肝炎的氧化应激,并且是非酒精性脂肪性肝炎中肝脏炎症的主要效应物,因此也促进肝纤维化;另外,在NAFLD中,血管生成受到高度刺激并促进NAFLD相关的肝细胞癌发生。然而,LSEC在非酒精性脂肪性肝炎相关性肝硬化中的作用尚未得到具体验证,需要进一步明确,以期为治疗提供新的思路和方向。
- 非酒精性脂肪性肝病 /
- 肝窦内皮细胞 /
- 病理过程
Abstract:
With the increasing incidence rate of nonalcoholic fatty liver disease( NAFLD) in Western developed countries and rich regions of China year by year,the treatment methods for NAFLD have been constantly improved and NAFLD has become a research hotspot. As an important physiological structure of the liver,liver sinus endothelial cells( LSECs) play an important role in the development and progression of NAFLD. This article summarizes the mechanism of action of LSECs in the pathogenesis of NAFLD,which included the following aspects:LSEC capillarization occurs in nonalcoholic fatty liver and promotes steatosis; meanwhile,LSECs contribute to oxidative stress in nonalcoholic steatohepatitis( NASH) and is a major effector of liver inflammation in NASH,thus promoting liver fibrosis; in addition,angiogenesis is highly stimulated and promotes NAFLD-related hepatocellular carcinoma in NAFLD. However,the role of LSECs in NASH-associated liver cirrhosis has not been validated,which needs to be further clarified to provide new ideas and directions for treatment.
- non-alcoholic fatty liver disease /
- liver sinusoidal endothelial cell /
- pathologic processes

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