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Drug resistance of direct-acting antivirals in genotype 2/3 hepatitis C virus
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摘要:
自针对HCV的直接抗病毒药物问世以来,超过95%的丙型肝炎患者可以获得治愈,但仍有极小部分患者面临治疗失败的情况。造成治疗失败的原因有很多,而HCV基因型以及病毒基因中的耐药相关替代（RAS）在其中有着一定的影响。介绍了目前对HCV基因2、3型的病毒株中,NS5B、NS5A基因片段相关的RAS位点,总结了其分布的情况以及在慢性丙型肝炎直接抗病毒药物初治患者与治疗失败患者之间RAS分布的差异。
Abstract:Since the development of direct-acting antivirals( DAAs) for hepatitis C virus( HCV),more than 95% of the patients with hepatitis C can be cured,but a very small proportion of patients still face treatment failure. There are many reasons for treatment failure,among which HCV genotype and resistance-associated substitutions( RASs) in virus genes show a certain impact. This article mainly introduces the RASs associated with the NS5 B and NS5 A gene fragments in genotype 2/3 HCV,summarizes the distribution of RASs,and compares the difference in the distribution of RASs between previously untreated chronic hepatitis C patients and patients with treatment failure.
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Key words:
- hepacivirus /
- antiviral agents /
- therapeutics
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