聚乙二醇干扰素治疗慢性乙型肝炎诱发血栓性血小板减少性紫癜1例报告

王欣茹; 肖丽; 耿爱文; 咸建春

doi:10.3969/j.issn.1001-5256.2020.11.028

聚乙二醇干扰素治疗慢性乙型肝炎诱发血栓性血小板减少性紫癜1例报告

DOI: 10.3969/j.issn.1001-5256.2020.11.028

泰州市人民医院肝病科

基金项目:

泰州市科技支撑计划（社会发展）项目（TS201813）；

详细信息

中图分类号: R512.62;R554.6;R558.2
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出版历程
- 出版日期: 2020-11-20

Pegylated interferon for treatment of chronic hepatitis B-induced thrombotic thrombocytopenic purpura:A case report

Department of Hepatology,Taizhou People's Hospital

Research funding:

摘要

摘要:
<正>目前用于治疗慢性乙型肝炎（CHB）的药物主要为干扰素（IFN）及核苷（酸）类药物（NAs）两类[1]。IFN治疗的优势包括疗程有限、应答更持久以及不产生耐药,也是目前有望提高功能性治愈率、达到理想治疗终点的主要药物[2]。但IFN不良反应较多,极少数可出现严重不良反应,如免疫性血小板减少性紫癜及血栓性血小板减少性紫癜（thrombotic thrombocytopenic purpura,TTP）[3]。通过报道1例可能与PEG-IFNα-2a治疗CHB相关的致死性TTP,以提醒临床医生加以注意。
- 乙型肝炎,慢性 /
- 紫癜,血栓性血小板减少性 /
- 干扰素α
- hepatitis B,chronic /
- purpura,thrombotic thrombocytopenic /
- interferon-alpha

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参考文献(15)

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