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circRNA在肝细胞癌中的作用机制

郭璇 谭为 王昌俊

引用本文:
Citation:

circRNA在肝细胞癌中的作用机制

DOI: 10.3969/j.issn.1001-5256.2020.10.039
基金项目: 

国家自然科学基金(81774261); 广东省中医药局课题(20191001,20171001); 

详细信息
  • 中图分类号: R735.7

Mechanism of action of circular RNAs in hepatocellular carcinoma

Research funding: 

 

  • 摘要: 肝细胞癌(HCC)是全球癌症相关死亡的主要原因之一,存在较高的病死率和复发率,生存率极低。环状RNA (circRNAs)是一类具有组织发育特异性表达模式的单链闭合环状RNA分子,在生物体内发挥调控作用,这些circRNAs通过充当miRNA海绵和靶向蛋白编码基因来调节HCC的进展,但其基本机制仍不清楚。归纳了circRNAs的形成机制及其生物学功能,并综述了circRNAs在HCC发病机制中的作用,提出其作为HCC诊断标志物和治疗靶点的潜在价值。

     

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  • 收稿日期:  2020-04-15
  • 出版日期:  2020-10-20
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