外泌体在肝细胞癌中的作用

姚韵婷; 周远忠; 刘俊

doi:10.3969/j.issn.1001-5256.2020.10.038

外泌体在肝细胞癌中的作用

DOI: 10.3969/j.issn.1001-5256.2020.10.038

遵义医科大学公共卫生学院

基金项目:

国家自然科学基金(81660552)；

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2020-03-29
- 出版日期: 2020-10-20

Role of exosomes in hepatocellular carcinoma

School of Public Health,Zunyi Medical University

Research funding:

摘要

摘要: 外泌体是由多种细胞释放的直径为50～150 nm的小膜囊泡,其含有miRNA、mRNA和蛋白质,具有调节受体细胞中信号传导途径的潜力。外泌体提供核酸和蛋白质参与协调细胞-细胞通讯和微环境调节。总结了外泌体在肝细胞癌（HCC）中作用相关研究的最新进展,分析了外泌体对HCC发生和进展的影响,包括化疗耐药性、上皮-间质转化、血管生成、转移和免疫应答。分析表明外泌体对于HCC治疗具有广阔前景。
- 癌,肝细胞 /
- 外泌体 /
- 肿瘤转移
Abstract: Exosomes are vesicles with a diameter of about 50-150 nm released by a variety of cells and contain miRNA,mRNA,and protein,with the potential to regulate the signal transduction pathways in receptor cells. Exosomes provide nucleic acids and proteins to coordinate cell-cell communication and microenvironment regulation. This article summarizes the latest research advances in the role of exosomes in hepatocellular carcinoma( HCC) and analyzes the effect of exosomes on the development and progression of HCC,including chemotherapy resistance,epithelial-mesenchymal transition,angiogenesis,metastasis,and immune response. The analysis shows that exosomes have a promising future in the treatment of HCC.
- carcinoma,hepatocellular /
- exosomes /
- neoplasm metastasis

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