外泌体在胰腺癌转移中的作用

李瑞; 张海蓉; 张景丽; 张宇艳; 李若畅

doi:10.3969/j.issn.1001-5256.2020.09.055

外泌体在胰腺癌转移中的作用

DOI: 10.3969/j.issn.1001-5256.2020.09.055

昆明医科大学第一附属医院消化内科

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中图分类号: R735.9
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出版历程
- 出版日期: 2020-09-20

Role of exosomes in the metastasis of pancreatic cancer

Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University

摘要

摘要:
尽管在过去几十年胰腺癌的诊断和治疗取得了较大的进展,但由于胰腺癌恶性程度高,发展迅速,浸润和转移性强,5年生存率仍低于10%。外泌体是一类纳米级的膜性囊泡,可由多种细胞分泌,其携带蛋白质、脂质、核酸等多种物质,参与细胞间物质运输、信息传递、肿瘤的发生发展及转移等生理病理过程。研究发现外泌体在胰腺癌的转移中起关键作用,外泌体通过上皮-间质转化、促进血管生成作用于肿瘤微环境,并影响转移前微环境的形成以及参与形成免疫抑制微环境等方式调控胰腺癌的转移。就外泌体在胰腺癌转移中的研究进展进行了综述。
- 胰腺肿瘤 /
- 外泌体 /
- 肿瘤转移
Abstract:
Although great achievements have been made in the diagnosis and treatment of pancreatic cancer in the past several decades,the5-year survival rate of this disease is still below 10% due to high degree of malignancy,rapid progression,and strong invasion and metastasis. Exosomes are a class of nanoscale membranous vesicles that can be secreted by a variety of cells,and they carry various substances including proteins,lipids,and nucleic acids and participate in various physiological and pathological processes,such as intercellular material transport,information transmission,and development,progression,and metastasis of tumor. Studies have shown that exosomes play an important role in the metastasis of pancreatic cancer and can regulate the metastasis of pancreatic cancer by promoting epithelial-mesenchymal transition and angiogenesis to act on tumor microenvironment,affecting the formation of premetastatic microenvironment,and participating in the formation of immunosuppression microenvironment. This article reviews the research advances in exosomes in the metastasis of pancreatic cancer.
- pancreatic neoplasms /
- exosomes /
- neoplasm metastasis

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参考文献(38)

[1] LUCHINI C,CAPELLI P,SCARPA A. Pancreatic ductal adenocarcinoma and its variants[J]. Surg Pathol Clin,2016,9(4):547-560.

[2] Pancreatic Cancer Committee of Chinese Anti-Cancer Association. Comprehensive guidelines for the diagnosis and treatment of pancreatic cancer(2018 version)[J]. J Clin Hepatol,2018,34(10):2109-2120.(in Chinese)中国抗癌协会胰腺癌专业委员会．胰腺癌综合诊治指南(2018版)[J]．临床肝胆病杂志，2018,34(10):2109-2120.

[3] KAMISAWA T,WOOD LD,ITOI T,et al. Pancreatic cancer[J]. The Lancet,2016,388(10039):73-85.

[4] SIEGEL RL,MILLER KD,JEMAL A. Cancer statistics,2019[J]. CA Cancer J Clin,2019,69(1):7-34.

[5] KALLURI R,LEBLEU VS. The biology,function,and biomedical applications of exosomes[J]. Science, 2020, 367(6478):eaau6977.

[6] XIE F,ZHOU X,FANG M,et al. Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy[J].Adv Sci,2019,6(24):1901779.

[7] TSCHUSCHKE M,KOCHEROVA I,BRYJA A,et al. Inclusion biogenesis,methods of isolation and clinical application of human cellular exosomes[J]. J Clin Med,2020,9(2):436.

[8] PAN BT,JOHNSTONE RM. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro:Selective externalization of the receptor[J]. Cell,1983,33(3):967-978.

[9] BATISTA IA,MELO SA. Exosomes and the future of immunotherapy in pancreatic cancer[J]. Int J Mol Sci,2019,20(3):567.

[10] van NIEL G,D'ANGELO G,RAPOSO G. Shedding light on the cell biology of extracellular vesicles[J]. Nat Rev Mol Cell Biol,2018,19(4):213-228.

[11] LI K,CHEN Y,LI A,et al. Exosomes play roles in sequential processes of tumor metastasis[J]. Int J Cancer,2019,144(7):1486-1495.

[12] CAMPBELL K,ROSSI F,ADAMS J,et al. Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors[J]. Nat Commun,2019,10(1):2311.

[13] DIEPENBRUCK M,CHRISTOFORI G. Epithelial-mesenchymal transition(EMT)and metastasis:Yes,no,maybe?[J].Curr Opin Cell Biol,2016,43:7-13.

[14] MAIER HJ,WIRTH T,BEUG H. Epithelial-mesenchymal transition in pancreatic carcinoma[J]. Cancers(Basel),2010,2(4):2058-2083.

[15] AIELLO NM,BAJOR DL,NORGARD RJ,et al. Metastatic progression is associated with dynamic changes in the local microenvironment[J]. Nat Commun,2016,7:12819.

[16] LI Z,JIANG P,LI J,et al. Tumor-derived exosomal lncSox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma[J]. Oncogene,2018,37(28):3822-3838.

[17] TANG P,TAO L,YUAN C,et al. Serum derived exosomes from pancreatic cancer patients promoted metastasis:An i TRAQ-based proteomic analysis[J]. Onco Targets Ther,2019,12:9329-9339.

[18] WANG X,LUO G,ZHANG K,et al. Correction:Hypoxic tumorderived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγto promote pancreatic cancer metastasis[J]. Cancer Res,2020,80(4):922.

[19] VONG S,KALLURI R. The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis[J]. Genes Cancer,2011,2(12):1139-1145.

[20] BRINTON LT,SLOANE HS,KESTER M,et al. Formation and role of exosomes in cancer[J]. Cell Mol Life Sci,2015,72(4):659-671.

[21] CAI H,LIU X,ZHENG J,et al. Long non-coding RNA taurine upregulated 1 enhances tumor-induced angiogenesis through inhibiting microRNA-299 in human glioblastoma[J].Oncogene,2017,36(3):318-331.

[22] NOLAN DJ,GINSBERG M,ISRAELY E,et al. Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration[J]. Dev Cell,2013,26(2):204-219.

[23] SHANG D,XIE C,HU J,et al. Pancreatic cancer cell-derived exosomal microRNA-27a promotes angiogenesis of human microvascular endothelial cells in pancreatic cancer via BTG2[J]. J Cell Mol Med,2020,24(1):588-604.

[24] CHIBA M,KUBOTA S,SATO K,et al. Exosomes released from pancreatic cancer cells enhance angiogenic activities via dynamin-dependent endocytosis in endothelial cells in vitro[J]. Sci Rep,2018,8(1):11972.

[25] LINTON SS,ABRAHAM T,LIAO J,et al. Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages[J]. PLo S One, 2018, 13(11):e0206759.

[26] NAZARENKO I,RANA S,BAUMANN A,et al. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation[J]. Cancer Res,2010,70(4):1668-1678.

[27] BLOMME A,FAHMY K,PEULEN O,et al. Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes[J]. Oncotarget,2016,7(50):83669-83683.

[28] LI J,LI Z,JIANG P,et al. Circular RNA IARS(circ-IARS)secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis[J]. J Exp Clin Cancer Res,2018,37(1):177.

[29] COSTA-SILVA B,AIELLO NM,OCEAN AJ,et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver[J]. Nat Cell Biol,2015,17(6):816-826.

[30] HOSHINO A,COSTA-SILVA B,SHEN TL,et al. Tumour exosome integrins determine organotropic metastasis[J]. Nature,2015,527(7578):329-335.

[31] RANA S,MALINOWSKA K,ZLLER M. Exosomal tumor microRNA modulates premetastatic organ cells[J]. Neoplasia,2013,15(3):281-295.

[32] WANG C,NING K,HU HH,et al. Research progress in tumor microenvironment of pancreatic cancer[J]. Chin J Dig Surg,2020,19(1):109-112.(in Chinese)王超，宁克，胡欢欢，等．胰腺癌肿瘤微环境的研究进展[J]．中华消化外科杂志，2020,19(1):109-112.

[33] BASSO D,GNATTA E,PADOAN A,et al. PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis[J].Oncotarget,2017,8(49):84928-84944.

[34] CHALMIN F,LADOIRE S,MIGNOT G,et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells[J]. J Clin Invest,2010,120(2):457-471.

[35] ZHOU M,CHEN J,ZHOU L,et al. Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203[J]. Cell Immunol,2014,292(1-2):65-69.

[36] DING G,ZHOU L,QIAN Y,et al. Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p[J]. Oncotarget,2015,6(30):29877-29888.

[37] ZECH D,RANA S,BCHLER MW,et al. Tumor-exosomes and leukocyte activation:An ambivalent crosstalk[J]. Cell Commun Signal,2012,10(1):37.

[38] QUE RS,LIN C,DING GP,et al. Increasing the immune activity of exosomes:The effect of miRNA-depleted exosome proteins on activating dendritic cell/cytokine-induced killer cells against pancreatic cancer[J]. J Zhejiang Univ Sci B,2016,17(5):352-360.

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