肝脏淋巴管新生在肝纤维化进展中的作用

石纳; 陈修利; 吴昊; 毛靖伟

doi:10.3969/j.issn.1001-5256.2020.09.038

肝脏淋巴管新生在肝纤维化进展中的作用

DOI: 10.3969/j.issn.1001-5256.2020.09.038

大连医科大学附属第一医院消化内科

基金项目:

国家自然科学基金资助项目(81500402)；辽宁省自然科学基金资助项目(20180530055)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2020-09-20

Role of hepatic lymphangiogenesis in the progression of liver fibrosis

Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University

Research funding:

摘要

摘要:
肝纤维化可进展为肝硬化、终末期肝病而导致预后不良。除与病理性血管生成和肝血窦重塑相关外,肝脏淋巴管新生在肝纤维化的进展中也起重要作用。简述了淋巴管标志物及其在肝脏中的表达,叙述了淋巴管新生在肝纤维化中的作用,归纳了肝脏巨噬细胞即Kupffer细胞和淋巴管内皮细胞在肝脏淋巴管新生中的作用,提出淋巴管新生可能成为干预肝纤维化的潜在靶点,对早期治疗及逆转肝纤维化、预防肝硬化及终末期肝病的发生具有重要作用。
- 肝硬化 /
- 淋巴管 /
- 枯否细胞
Abstract:
Liver fibrosis can progress to liver cirrhosis and end-stage liver disease,which may lead to poor prognosis. In addition to pathological angiogenesis and hepatic sinusoid remodeling,hepatic lymphangiogenesis also plays an important role in the progression of liver fibrosis. This article briefly describes lymphatic vessel markers and their expression in the liver,introduces the role of lymphangiogenesis in liver fibrosis,and reviews the role of liver macrophages( Kupffer cells) and lymphatic endothelial cells in lymphangiogenesis. It is pointed out lymphangiogenesis may become a potential target for the intervention of liver fibrosis,which plays an important role in the early treatment and reversal of liver fibrosis and the prevention of liver cirrhosis and end-stage liver disease.
- liver cirrhosis /
- lymphatic vessels /
- Kupffer cells

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参考文献(37)

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