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吉林地区不同肝病患者血清铜蓝蛋白水平分析

王莎莎 华芳 焦永庚 秦二云 智一晓 庞梦圆 徐洪芹 迟秀梅 牛俊奇 华瑞

引用本文:
Citation:

吉林地区不同肝病患者血清铜蓝蛋白水平分析

DOI: 10.3969/j.issn.1001-5256.2020.09.023
基金项目: 

吉林省科技发展计划基金(20200201499JC); 

详细信息
  • 中图分类号: R575

Serum level of ceruloplasmin in patients with different liver diseases in Jilin,China

Research funding: 

 

  • 摘要: 目的探讨不同病因、不同疾病阶段的肝病患者血清铜蓝蛋白水平。方法选取吉林大学第一医院肝胆胰内科2012年1月-2018年1月住院的共1077例肝病患者,分析不同肝病患者的血清铜蓝蛋白水平。应用Kruskal-Wallis H检验比较不同肝功能状态的病毒相关性肝病患者的铜蓝蛋白水平,应用Spearman相关性分析方法评估铜蓝蛋白与其他指标之间的相关性。结果在肝豆状核变性组,97.6%(41/42)的患者血清铜蓝蛋白水平低于0.2 g/L,其中88.1%(37/42)低于0.10 g/L。不同肝功能状态的病毒相关性肝病患者血清铜蓝蛋白水平差异显著,其中慢性病毒性肝炎、重症病毒性肝炎以及病毒性肝炎肝硬化患者的血清铜蓝蛋白水平均低于急性病毒性肝炎和病毒相关性肝癌患者(P值分别为0.005、<0.001、0.001、0.027、<0.001、0.001)。在非肝豆状核变性肝病组,24.3%(251/1035)的患者铜蓝蛋白低于0.2 g/L,0.2%低于0.1 g/L。非肝豆状核变性肝病患者的血清铜蓝蛋白与白蛋白、前白蛋白呈正相关,与凝血酶原时间呈负相关(r值分别为0.068、0.09...

     

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  • 收稿日期:  2020-05-17
  • 出版日期:  2020-09-20
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