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基于MELD评分分层分析人工肝治疗对平台期肝衰竭患者短期预后的影响

兰小勤 纪雅丽 陈金军 周福元 文维群

引用本文:
Citation:

基于MELD评分分层分析人工肝治疗对平台期肝衰竭患者短期预后的影响

DOI: 10.3969/j.issn.1001-5256.2020.09.019
基金项目: 

国家科技重大专项子课题(2018ZX10302-206-004); 

详细信息
  • 中图分类号: R575.3

Effect of artificial liver support therapy on the short-term prognosis of patients with liver failure in the plateau stage: A stratified analysis based on Model for End-Stage Liver Disease score

Research funding: 

 

  • 摘要:

    目的对平台期肝衰竭患者进行MELD评分分层后,研究人工肝治疗对其短期(28 d及90 d内)病死率的影响。方法回顾性纳入2015年1月-2019年4月南方医科大学南方医院收治的肝衰竭患者187例,其中人工肝组73例,非人工肝组114例。按平台期不同的MELD评分分层分析2组间28 d、90 d病死率的差异,存活者的住院费用和住院日的差异,以及人工肝不良反应发生率。计量资料2组间比较采用t检验,计数资料2组间比较采用χ2检验或Fisher确切概率法。结果人工肝治疗可显著降低MELD评分30~39分[人工肝组(5.9%) vs非人工肝组(39.6%),P<0.001]及40分[人工肝组(25.0%) vs非人工肝组(72.7%),P <0.05]的平台期肝衰竭患者28 d病死率。人工肝治疗可降低MELD评分30~39分平台期肝衰竭患者90 d病死率[人工肝组(23.5%) vs非人工肝组(62.3%),P <0.001]。人工肝治疗不能明显缩短存活患者的平均住院时间(p>0.05);人工肝治疗对90 d内存活患者的住院总费用无明显影响(P> 0.05);人...

     

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