缺氧微环境与肝病发生发展的关系

李志国; 杨先照; 李小科; 马浔; 王姗; 张梅; 叶永安

doi:10.3969/j.issn.1001-5256.2020.08.047

缺氧微环境与肝病发生发展的关系

DOI: 10.3969/j.issn.1001-5256.2020.08.047

1. 北京中医药大学东直门医院消化科
2. 北京中医药大学肝病研究所
3. 北京杏园金方国医医院
4. 北京中医药大学东直门医院检验科

基金项目:

国家自然科学基金青年科学基金项目(81603555)；北京市自然科学基金青年科学基金项目(7174319)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2020-08-20

Association of hypoxic microenvironment with the development and progression of liver diseases

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Research funding:

摘要

摘要:
缺氧微环境是肝病的一种普遍现象,贯穿于肝病发生发展的始终。近年来对肝纤维化及肝细胞癌组织缺氧微环境的研究也越来越受到重视。缺氧诱导因子是目前发现的最重要的缺氧应激因子。综述了肝脏及肝病的缺氧微环境特点,进一步探讨了缺氧诱导因子的过表达与肝细胞损伤、纤维化形成及肝细胞恶性转化的关系。
- 肝疾病 /
- 缺氧微环境 /
- 缺氧诱导因子
Abstract:
Hypoxic microenvironment is a common phenomenon of liver diseases and runs through the whole process of the development and progression of liver diseases.In recent years,the research on liver fibrosis and hypoxic microenvironment of hepatocellular carcinoma has attracted more and more attention.Hypoxia-inducible factor(HIF) is the most important hypoxic stress factor found at present.This article reviews the characteristics of hypoxic microenvironment in the liver and liver diseases and further elaborates on the association of HIF overexpression with hepatocyte damage,formation of fibrosis,and malignant transformation of hepatocytes.
- liver diseases /
- hypoxic microenvironment /
- hypoxia-inducible factor

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参考文献(53)

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