高良姜素对肝癌细胞抑制作用的机制

李程; 张惠文; 容鹏飞

doi:10.3969/j.issn.1001-5256.2020.08.040

高良姜素对肝癌细胞抑制作用的机制

DOI: 10.3969/j.issn.1001-5256.2020.08.040

中南大学湘雅三医院放射科

基金项目:

国家自然科学基金项目(81771827)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2020-08-20

Mechanism of the inhibitory effect of galangin on hepatoma cells

Department of Radiology, The Third Xiangya Hospital of Central South University

Research funding:

摘要

摘要:
肝细胞癌(HCC)病死率较高,尽管已有较多的治疗手段,但迄今为止HCC的临床治疗效果仍然欠佳,患者预后差。因此,临床上有必要寻找一种治疗HCC的新药以提高患者的生存率。介绍了一种新的抗肿瘤药物高良姜素,其可以通过抑制细胞增殖、促进凋亡、诱导自噬,以及抑制转移等途径发挥抗癌作用。除此之外,高良姜素还可抑制肝癌新生血管形成、逆转多药耐药以及加强药物的协同作用等。因此,认为高良姜素具有广阔的临床应用前景,期待更多的研究聚焦于高良姜素抗肝癌细胞的作用机制,为其临床转化应用提供充分的科学依据。
- 癌,肝细胞 /
- 高良姜素 /
- 肿瘤抑制蛋白质类
Abstract:
The mortality rate of hepatocellular carcinoma(HCC) remains high,and although there have been several treatment methods,HCC patients still have poor treatment outcome and prognosis in clinical practice.Therefore,it is necessary to find a new drug for the treatment of HCC to improve patients' survival rate.This article introduces a new antitumor drug,galangin,which can exert an antitumor effect by inhibiting cell proliferation,promoting apoptosis,inducing autophagy,and inhibiting metastasis.In addition,galangin can also inhibit angiogenesis in liver cancer,reverse multidrug resistance,and enhance the synergistic effect between drugs.Therefore,galangin is believed to have a promising future in clinical practice,and it is expected that more studies will focus on the anti-hepatoma cell mechanism of galangin to provide a scientific basis for the clinical translation of galangin.
- carcinoma,hepatocellular /
- galangin /
- tumor suppressor proteins

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参考文献(32)

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