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调节性B淋巴细胞在自身免疫性肝炎发生发展中的作用机制

童聪 向晓星

引用本文:
Citation:

调节性B淋巴细胞在自身免疫性肝炎发生发展中的作用机制

DOI: 10.3969/j.issn.1001-5256.2020.07.046
详细信息
  • 中图分类号: R575.1

Mechanism of action of regulatory B cells in the development and progression of autoimmune hepatitis

  • 摘要: 自身免疫性肝炎是一种自身免疫性疾病,目前机制不清,主要认为与机体免疫失衡有关。炎症性疾病中调节性B淋巴细胞(Breg)主要通过分泌IL-10抑制炎症反应,抑制CD4+T淋巴细胞分化为辅助性T淋巴细胞1和辅助性T淋巴细胞17。自身免疫性肝炎患者外周血IL-10水平降低,Breg数量及功能降低,导致其不能有效的抑制炎症反应,提示Breg在自身免疫性肝炎发病起到了一定的作用。综述了Breg亚群在自身免疫性肝炎中的作用机制。

     

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