OPG/RANKL/RANK信号通路在非酒精性脂肪性肝病进展中的作用

向照; 杨晋辉

doi:10.3969/j.issn.1001-5256.2020.07.040

OPG/RANKL/RANK信号通路在非酒精性脂肪性肝病进展中的作用

DOI: 10.3969/j.issn.1001-5256.2020.07.040

向照,
杨晋辉

昆明医科大学第二附属医院消化内科

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中图分类号: R575.5
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出版历程
- 出版日期: 2020-07-20

Role of the OPG/RANKL/RANK signaling pathway in the progression of nonalcoholic fatty liver disease

Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China

摘要

摘要:
非酒精性脂肪性肝病（NAFLD）已成为全球范围内最常见的肝脏疾病,在现有基础上更好诊断、治疗NAFLD也愈发迫切。骨保护素（OPG）/NF-κB受体活化因子（RANKL）/NF-κB受体活化因子受体（RANK）信号通路是参与骨代谢平衡的重要信号通路。分别介绍了OPG、RANKL、RANK及OPG/RANKL/RANK系统,简述了OPG/RANKL/RANK信号通路通过激活NF-κB调节炎症因子生成,促使NAFLD发展的研究现状。指出OPG/RANKL/RANK系统可作为NAFLD治疗的潜在新靶点。
- 非酒精性脂肪性肝病 /
- 骨保护素 /
- NF-κB /
- 信号传导
Abstract:
Nonalcoholic fatty liver disease( NAFLD) has now become the most common liver disease around the world,and there is an urgent need for better diagnosis and treatment of NAFLD. The osteoprotegerin( OPG)/receptor activator of nuclear factor-kappa B ligand( RANKL)/receptor activator of nuclear factor-kappa B( RANK) signaling pathway is an important signaling pathway involved in the balance of bone metabolism. This article introduces the OPG,RANKL,RANK,and OPG/RANKL/RANK systems and elaborates on the current research on the role of the OPG/RANKL/RANK signaling pathway in regulating the production of inflammatory factors and promoting the progression of NAFLD by activating NF-κB. It is pointed out that the OPG/RANKL/RANK system may be used as a potential target for the treatment of NAFLD.
- non-alcoholic fatty liver disease /
- osteoprotegerin /
- NF-kappa B /
- signal transduction

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参考文献(29)

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