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非酒精性脂肪性肝病更名的临床意义

曾静 范建高

引用本文:
Citation:

非酒精性脂肪性肝病更名的临床意义

DOI: 10.3969/j.issn.1001-5256.2020.06.002
基金项目: 

国家科技部精准诊疗课题(2017YFC0908900); 国家自然科学基金(81873536); 上海市领军人才培养计划(2017019); 上海交通大学医学院高水平地方高校创新团队(2018); 

详细信息
  • 中图分类号: R575.5

Clinical significance of renaming nonalcoholic fatty liver disease

Research funding: 

 

  • 摘要:

    非酒精性脂肪性肝炎和非酒精性脂肪性肝病(NAFLD)在20世纪80年代首次用于描述肝组织学改变与酒精性肝病相似但患者无过量饮酒且无其他损肝因素存在。40年来,NAFLD的研究越来越深入且进展迅速。然而,一直未变的NAFLD命名对日常临床实践和当前临床试验已产生了一定的阻碍。为了克服旧术语的缺陷,日前国际共识小组建议应用代谢相关脂肪性肝病(MAFLD)取代NAFLD,并进一步提出既全面又简便的MAFLD新定义用于临床诊断,从而使MAFLD有别于其他肝脏疾病;同时,建议MAFLD的疾病评估和严重程度分层应该超出当前的二分类法则。NAFLD更名为MAFLD将成为优化临床实践,提高临床研究效率,并使医生、患者群体获益的一项重要举措。

     

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  • 出版日期:  2020-06-20
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