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非酒精性脂肪性肝病更名带来的新思考

高鑫

引用本文:
Citation:

非酒精性脂肪性肝病更名带来的新思考

DOI: 10.3969/j.issn.1001-5256.2020.06.001
详细信息
  • 中图分类号: R575.5

New thoughts about renaming nonalcoholic fatty liver disease

  • 摘要:

    非酒精性脂肪性肝病(NAFLD)是一种代谢紊乱相关的多系统疾病,在肥胖和2型糖尿病(T2DM)患者中更为常见,而且与这两个共患疾病有着相似的不良结局。长期以来,NAFLD的重点强调肝脏病变和肝病相关结局,内分泌科医生按照目前糖尿病临床指南处理T2DM的同时往往忽视了对肝脏病变的筛查、诊断与处理。因此,在实际工作中,将NAFLD更名为代谢相关脂肪性肝病有着重要的现实意义。以降低肝脂肪含量为目标的防治T2DM的策略需要多学科临床与基础合作,以共同理念防治肥胖、脂肪肝、糖尿病,才能将最常见的慢性病防治落到实处。

     

  • [1] ESLAM M,NEWSOME PN,SARIN SK,et al. A new definition for metabolic dysfunction-associated fatty liver disease:An international expert consensus statement[J]. J Hepatol,2020.[Online ahead of print]
    [2] LI J,ZOU B,YEO YH,et al. Prevalence,incidence,and outcome of non-alcoholic fatty liver disease in Asia,1999-2019:A systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol,2019,4(5):389-398.
    [3] FRIEDMAN SL,NEUSCHWANDER-TETRI BA,RINELLA M,et al. Mechanisms of NAFLD development and therapeutic strategies[J]. Nat Med,2018,24(7):908-922.
    [4] MOHAMMED E,ARUN JS,JACOB G,et al. MAFLD:A consensus-driven proposed nomenclature for metabolic associated fatty liver disease[J]. Gastroenterology,2020,158(7):1999-2014.
    [5] GASTALDELLI A,CUSI K. From NASH to diabetes and from diabetes to NASH:Mechanisms and treatment options[J].JHEP Rep,2019,1(4):312-328.
    [6] AMARAPURKAR DN,HASHIMOTO E,LESMANA LA,et al.How common is non-alcoholic fatty liver disease in the AsiaPacific region and are there local differences?[J]. J Gastroenterol Hepatol,2007,22(6):788-793.
    [7] POLYZOS SA,KOUNTOURAS J,MANTZOROS CS. Obesity and nonalcoholic fatty liver disease:From pathophysiology to therapeutics[J]. Metabolism,2019,92:82-97.
    [8] BRIL F,CUSI K. Management of nonalcoholic fatty liver disease in patients with type 2 diabetes:A call to action[J]. Diabetes Care,2017,40(3):419-430.
    [9] BRIL F,CUSI K. Nonalcoholic fatty liver disease:The new complication of type 2 diabetes mel itus[J]. Endocrinol Metab Clin North Am,2016,45(4):765-781.
    [10] MARCHESINI G,DAY CP,DUFOUR JF,et al. EASL-EASDEASO clinical practice guidelines for the management of non-alcoholic fatty liver disease[J]. J Hepatol,2016,64(6):1388-1402.
    [11] Chinese Society of Endocrinology,Chinese Medical Association. Consensus for diagnosis and treatment of nonalcoholic fatty liver diseases and metabolic disorders(2nd Edition)[J].J Clin Hepatol,2018,34(10):2103-2108.(in Chinese)中华医学会内分泌学分会.非酒精性脂肪性肝病与相关代谢紊乱诊疗共识(第二版)[J].临床肝胆病杂志,2018,34(10):2103-2108.
    [12] BIAN H,ZHU X,XIA M,et al. Impact of type 2 diabetes on nonalcoholic steatohe patitis and advanced fibrosis in patients with nonalcoholic fatty liver disease[J]. Endocr Pract,2020,26(4):444-453.
    [13] PORIES WJ,MACDONALD KG Jr,MORGAN EJ,et al. Surgical treatment of obesity and its effect on diabetes:10-y follow-up[J]. Am J Clin Nutr,1992,55(2 Suppl):582s-585s.
    [14] LEAN ME,LESLIE WS,BARNES AC,et al. Primary care-led weight management for remission of type 2 diabetes(DiRECT):An open-label,cluster-randomised trial[J]. Lancet,2018,391(10120):541-551.
    [15] LEAN M,LESLIE WS,BARNES AC,et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes:2-year results of the DiRECT openlabel,cluster-randomised trial[J]. Lancet Diabetes Endocrinol,2019,7(5):344-355.
    [16] TAYLOR R,AL-MRABEH A,SATTAR N. Understanding the mechanisms of reversal of type 2 diabetes[J]. Lancet Diabetes Endocrinol,2019,7(9):726-736.
    [17] TAYLOR R,BARNES AC. Can type 2 diabetes be reversed and how can this best be achieved? James Lind Alliance research priority number one[J]. Diabet Med,2019,36(3):308-315.
    [18] PETRICK JL,KELLY SP,ALTEKRUSE SF,et al. Future of hepatocellular carcinoma incidence in the united states forecast through 2030[J]. J Clin Oncol,2016,34(15):1787-1794.
    [19] HESTER D,GOLABI P,PAIK J,et al. Among medicare patients with hepatocellular carcinoma,non-alcoholic fatty liver disease is the most common etiology and cause of mortality[J]. J Clin Gastroenterol,2020,54(5):459-467.
    [20] ANSTEE QM,REEVES HL,KOTSILITI E,et al. From NASH to HCC:Current concepts and future challenges[J]. Nat Rev Gastroenterol Hepatol,2019,16(7):411-428.
    [21] FRIEDMAN SL,NEUSCHWANDER-TETRI BA,RINELLA M,et al. Mechanisms of NAFLD development and therapeutic strategies[J]. Nat Med,2018,24(7):908-922.
    [22] ALUKAL JJ,THULUVATH PJ. Reversal of NASH fibrosis with pharmacotherapy[J]. Hepatol Int,2019,13(5):534-545.
    [23] FIORUCCI S,BIAGIOLI M,DISTRUTTI E. Future trends in the treatment of non-alcoholic steatohepatitis[J]. Pharmacol Res,2018,134:289-298.
    [24] JOHNSTON MP,PATEL J,BYRNE CD. Multi-drug approaches to NASH:What's in the development pipeline?[J]. Expert Opin Investig Drugs,2020,29(2):143-150.
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  • 出版日期:  2020-06-20
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