自身免疫性肝炎的标准治疗和潜在治疗靶点

王睿; 王绮夏; 马雄

doi:10.3969/j.issn.1001-5256.2020.04.005

自身免疫性肝炎的标准治疗和潜在治疗靶点

DOI: 10.3969/j.issn.1001-5256.2020.04.005

上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所

基金项目:

国家自然科学基金项目(81770564,81790634,81620108002,81771732,81830016)；上海市卫生计生系统优秀青年医学人才培养计划(2017YQ037)；上海市青年科技启明星计划(18QA1402700)；

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中图分类号: R575.1
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出版历程
- 收稿日期: 2020-02-07
- 出版日期: 2020-04-20

Standard therapy and potential therapeutic targets for autoimmune hepatitis

Division of Gastroenterology and Hepatology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University & Shanghai Institute of Digestive Diseases

Research funding:

摘要

摘要: 自身免疫性肝炎(AIH)是一种由自身免疫反应介导的肝脏炎症性疾病,未经积极治疗可发展为肝衰竭、肝硬化。AIH的治疗目标为获得生化缓解和组织学缓解。目前标准治疗方案为免疫抑制剂疗法,即泼尼松(龙)联合硫唑嘌呤或泼尼松(龙)单药治疗。患者对标准治疗方案不耐受或应答不佳时,可考虑启动包括吗替麦考酚酯在内的二线治疗方案。近年来研究表明,免疫功能、肠道菌群、维生素D、心理状态等多种因素参与AIH的发生发展,可作为AIH的潜在治疗靶点。综述了近年来AIH治疗方案的相关研究及潜在治疗靶点。
- 肝炎,自身免疫性 /
- 治疗学 /
- 分子靶向治疗
Abstract: Autoimmune hepatitis( AIH) is a liver inflammatory disease mediated by autoimmune response and may progress to liver failure and liver cirrhosis without treatment. The goal of AIH treatment is to achieve biochemical remission and histological remission. Currently immunosuppressant therapy is the standard therapy for AIH,i. e.,prednisone/prednisolone alone or combined with azathioprine. For the patients who do not tolerate or have poor response to the standard therapy,second-line treatment regimen,including mycophenolate mofetil,can be considered. Recent studies have shown that various factors participate in the development and progression of AIH,such as immune function,gut microbiota,vitamin D,and mental state,which may become the potential therapeutic targets for AIH. This article reviews related studies on the standard therapies for AIH and highlights the potential therapeutic targets for AIH treatment.
- hepatitis,autoimmune /
- therapeutics /
- molecular targeted therapy

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参考文献(51)

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