中性粒细胞胞外诱捕网的形成机制及在肝病中的作用

曹林; 李茜; 纪龙珊; 高月求; 李曼

doi:10.3969/j.issn.1001-5256.2020.01.049

中性粒细胞胞外诱捕网的形成机制及在肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2020.01.049

1. 上海市中医临床重点实验室细胞免疫学实验室
2. 上海中医药大学附属曙光医院肝病科

基金项目:

国家自然科学基金面上项目(81673767)；上海市科委科技支撑项目(16401970600)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2020-01-20

Formation mechanism of neutrophil extracellular traps and their role in liver diseases

Shanghai Key Laboratory of Traditional Chinese Clinical Medicine & Laboratory of Cellular Immunology, Shanghai 200120, China

Research funding:

摘要

摘要:
中性粒细胞胞外诱捕网(NETs)是近年来新发现的中性粒细胞杀灭病原体的一种新的免疫机制。NETs的主要成分是DNA,上面附着大小不一的颗粒蛋白。NETs在肝缺血再灌注损伤、慢性乙型肝炎、肝硬化和肝癌等肝病中扮演着不同的角色。阐述了NETs的形成机制、结构组成和其在肝病中作用的研究进展。
- 胞外诱捕网 /
- 乙型肝炎,慢性 /
- 肝硬化 /
- 肝肿瘤
Abstract:
Neutrophil extracellular traps(NETs) have recently been found to be a new immune mechanism for neutrophils to kill pathogens.The main component of NETs is DNA,with granular proteins of different sizes attached to the surface. NETs play different roles in various liver diseases such as hepatic ischemia-reperfusion injury,chronic hepatitis B,liver cirrhosis,and liver cancer. This article reviews the formation mechanism,structure,and role of NETs in liver diseases.
- extracellular traps /
- hepatitis B,chronic /
- liver cirrhosis /
- liver neoplasms

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参考文献(41)

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