雌激素受体α基因多态性与乙型肝炎肝硬化的关系

程娜; 杨京

doi:10.3969/j.issn.1001-5256.2020.01.044

雌激素受体α基因多态性与乙型肝炎肝硬化的关系

DOI: 10.3969/j.issn.1001-5256.2020.01.044

程娜,
杨京

贵州医科大学附属医院感染科

详细信息

中图分类号: R512.62;R575.2
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出版历程
- 收稿日期: 2019-08-21
- 出版日期: 2020-01-20

Association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis

Cheng Na,
Yang Jing

Department of Infectious Diseases,Guizhou Medical University

摘要

摘要: 目前,乙型肝炎肝硬化对公众的健康及国家的发展仍有重大的影响。乙型肝炎肝硬化的发生发展与雌激素有关,雌激素通过与雌激素受体结合发挥作用,雌激素受体的表达和功能状态受雌激素受体基因多态性的影响。介绍了雌激素与雌激素受体α基因的结构和生物学特征,以及分别与乙型肝炎肝硬化发病的相关性,指出雌激素的异常表达可能与乙型肝炎肝硬化的发生发展有关。然而可能由于研究的基因位点、环境、地点等不同,最终得出的雌激素受体α基因多态性与乙型肝炎肝硬化相关性的结果不完全一致。
- 雌激素受体α /
- 多态现象,遗传 /
- 乙型肝炎 /
- 肝硬化
Abstract: At present,hepatitis B cirrhosis still has a major impact on public health and national development. The development and progression of hepatitis B cirrhosis is associated with estrogen. Estrogen acts by binding to estrogen receptors,and the expression and functional status of estrogen receptors are affected by estrogen receptor gene polymorphisms. This article mainly introduces the structure and biological characteristics of estrogen and estrogen receptor α gene and their association with the pathogenesis of hepatitis B cirrhosis,and it is pointed out that the abnormal expression of estrogen may be associated with the development and progression of hepatitis B cirrhosis. However,due to the differences in genetic loci,environment,and location between studies,the results of the association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis may not be completely consistent.
- estrogen receptor alpha /
- polymorphism,genetic /
- hepatitis B /
- liver cirrhosis

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参考文献(31)

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