内质网应激和细胞自噬对肝细胞凋亡的影响

弓晶; 解新科

doi:10.3969/j.issn.1001-5256.2019.12.041

内质网应激和细胞自噬对肝细胞凋亡的影响

DOI: 10.3969/j.issn.1001-5256.2019.12.041

弓晶,
解新科

1. 陕西中医药大学
2. 陕西中医药大学附属医院肝病二科

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-07-08
- 出版日期: 2019-12-20

Effect of endoplasmic reticulum stress and autophagy on hepatocyte apoptosis

Shaanxi University of Chinese Medicine

摘要

摘要: 内质网应激和自噬是两把双刃剑,当细胞内环境紊乱时,未折叠蛋白质反应通过3条信号通路来减少蛋白质合成、促进蛋白质降解、增加蛋白质折叠以恢复细胞内稳态,过度应激则会激活一系列信号分子诱导细胞凋亡;自噬是人体自我降解保护途径,通过自噬泡-溶酶体复合物摄取并分解胞内受损或有害的大分子物质,促进细胞新陈代谢,而过度自噬亦会引起细胞凋亡。内质网应激和自噬在肝细胞凋亡过程中发挥重要作用。因此,二者可作为未来药物研究靶点,为肝细胞相关性疾病提供诊疗策略。
- 内质网应激 /
- 自噬 /
- 细胞凋亡 /
- 肝细胞
Abstract: Endoplasmic reticulum stress and autophagy are two two-edged swords. On the one hand,in case of intracellular environment disturbance,unfolded protein response reduces protein synthesis,promotes protein degradation,and increases protein folding to restore intracellular homeostasis through three signaling pathways,while excessive stress activates a series of signaling molecules to induce apoptosis; on the other hand,autophagy is a protective pathway for self-degradation in human body and can absorb and decompose damaged or harmful macromolecular substances in cells through autophagic vacuole-lysosome complex and promote cell metabolism,while excessive autophagy also causes apoptosis. Endoplasmic reticulum stress and autophagy play important roles in the process of hepatocyte apoptosis. Therefore,these two molecular mechanisms may serve as targets for future drug research and provide therapeutic and diagnostic strategies for hepatocellular diseases.
- endoplasmic reticulum stress /
- autophagy /
- apoptosis /
- hepatocytes

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参考文献(40)

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