中医药调控自噬治疗肝癌的研究现状

顾欢; 白长川; 刘柳; 程秋骆; 朱英

doi:10.3969/j.issn.1001-5256.2019.11.043

中医药调控自噬治疗肝癌的研究现状

DOI: 10.3969/j.issn.1001-5256.2019.11.043

1. 大连医科大学附属第一医院中西医结合肝病中心
2. 大连市中医院

基金项目:

国家自然科学基金项目(81673728)；

详细信息

中图分类号: R273
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- 被引次数: 0
出版历程
- 收稿日期: 2019-07-15
- 出版日期: 2019-11-20

Research advances in traditional Chinese medicine regulation of autophagy in treatment of liver cancer

Liver Disease Center for Combined TCM and Western Medicine,The First Affiliated Hospital of Dalian Medical University

Research funding:

摘要

摘要: 近些年自噬成为防治肿瘤的研究热点,自噬具有双向调节作用,既可通过降解细胞内错误折叠的蛋白质、清除受损的细胞器等为体内正常细胞和肿瘤细胞提供能量和稳定的内环境,又可引发肿瘤细胞自噬性死亡。如何更好地介导自噬起到抑制肿瘤发生发展的作用,在西药研究遇到平台期时,中医药低毒性、多靶点、多途径的优势便体现出来了。综述了近10年中医药对肝癌自噬调控的研究进展,并针对目前研究存在的问题进行分析和探索,希望能为后续肝癌的研究提供参考和新的思路。
- 中草药 /
- 肝肿瘤 /
- 自噬
Abstract: Autophagy has become a research hotspot in the prevention and treatment of tumor in recent years. With the help of the bidirectional regulatory effect of autophagy,it can not only provide energy and a stable internal environment for normal and tumor cells by clearing misfolded proteins and damaged organelles in cells,but also induce autophagic death of tumor cells. Traditional Chinese medicine has advantages over Western medicine in better mediating autophagy to inhibit tumor development and progression,with the features of low toxicity,multiple targets,and multiple pathways. With an increasing number of studies on autophagy in traditional Chinese medicine,this article reviews the research advances in the effect of traditional Chinese medicine in autophagy in liver cancer in the past 10 years and explores and analyzes existing problems,hoping to provide a reference and new ideas for subsequent research on liver cancer.
- drugs,Chinese herbal /
- liver neoplasms /
- autophagy

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