肠道菌群介导的免疫反应在慢性HBV感染中的作用

高慧; 刘守胜; 赵真真; 辛永宁

doi:10.3969/j.issn.1001-5256.2019.11.039

肠道菌群介导的免疫反应在慢性HBV感染中的作用

DOI: 10.3969/j.issn.1001-5256.2019.11.039

1. 青岛大学附属青岛市市立医院感染性疾病科
2. 青岛大学附属青岛市市立医院中心实验室

基金项目:

国家自然科学基金面上项目(31770837)；

详细信息

中图分类号: R512.62
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- 被引次数: 0
出版历程
- 收稿日期: 2019-07-02
- 出版日期: 2019-11-20

Role of intestinal flora-mediated immune response in chronic hepatitis B virus infection

Department of Infectious Diseases,Qingdao Municipal Hospital Affiliated to Qingdao University

Research funding:

摘要

摘要: HBV感染可引起急性或慢性肝损伤,而HBV相关的肝硬化和肝细胞癌通常会导致病死率增加,其发病机制可能与免疫反应相关。肠道菌群在宿主的代谢和免疫调节中扮演着重要的角色,对"肠肝轴"和肠道菌群的研究发现,肠道微生物群的结构变化、细菌易位以及由此产生的免疫损伤会影响慢性乙型肝炎基础上肝脏炎症的发生和发展。总结和讨论肠道菌群在慢性乙型肝炎中的免疫作用,并探讨基于肠道菌群的HBV感染的潜在治疗方法。
- 乙型肝炎,慢性 /
- 胃肠道微生物组 /
- 免疫调节 /
- 粪便微生物群移植
Abstract: Hepatitis B virus( HBV) infection can cause acute or chronic liver injury. Chronic hepatitis B( CHB)-related liver cirrhosis and hepatocellular carcinoma usually lead to an increase in mortality,and their pathogenesis may be associated with immune response. Intestinal flora plays an important role in host metabolism and immune regulation,and the studies on“gut-liver axis”and intestinal flora have shown that the structural change of intestinal flora,bacterial translocation,and related immunologic injury may affect the development and progression of liver inflammation on the basis of CHB. This article summarizes and discusses the immunological role of intestinal flora in CHB and explores the potential treatment methods for HBV infection based on intestinal flora.
- hepatitis B,chronic /
- gastrointestinal microbiome /
- immunomodulation /
- fecal microbiota transplantation

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参考文献(39)

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