过氧化物酶体增殖激活受体α在肝脏疾病中的作用及机制

张丹; 马岚青

doi:10.3969/j.issn.1001-5256.2019.10.049

过氧化物酶体增殖激活受体α在肝脏疾病中的作用及机制

DOI: 10.3969/j.issn.1001-5256.2019.10.049

张丹,
马岚青

昆明医科大学第一附属医院消化内科

基金项目:

国家自然科学基金(81760108; 81560099)；云南省重点项目(2018FA039)；云南省教育厅科学研究基金项目(2019Y0353,2016ZDX054)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-05-08
- 出版日期: 2019-10-20

Research advances in the role and mechanism of peroxisome proliferator-activated receptor alpha in liver diseases

Department of Gastroenterology,The First Affiliated Hospital of Kunming Medical University

Research funding:

摘要

摘要: 过氧化物酶体增殖激活受体α(PPARα)是核受体超家族成员,在脂质代谢中起着中心调控作用,近年来发现PPARα激动剂在非酒精性脂肪性肝病的预防和治疗中起着关键作用,在其他肝脏疾病中也有相关报道。综述了PPARα在非酒精性脂肪性肝病、酒精性肝病、病毒性肝炎、胆汁淤积性肝病、药物性肝损伤、肝癌中的作用及机制,为PPARα相关的老药新用方面的研究提供参考。
- PPARα /
- 肝疾病 /
- 脂肪肝
Abstract: Peroxisome proliferator-activated receptor alpha(PPARα) is a member of the nuclear receptor superfamily and plays a central regulatory role in lipid metabolism. Recent studies have found that PPARα agonists play a key role in the prevention and treatment of nonalcoholic fatty liver disease,which has also been reported in other liver diseases. This article reviews the role and mechanism of PPARα in nonalcoholic fatty liver disease,alcoholic liver disease,viral hepatitis,cholestatic liver disease,drug-induced liver injury,and hepatocellular carcinoma,so as to provide a reference for the research on the new application of conventional drugs associated with PPARα.
- PPAR alpha /
- liver diseases /
- fatty liver

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参考文献(48)

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