自身免疫性肝炎发病机制的研究现状

曹亦楠; 周桂琴; 王宪波; 李斌; 冯颖; 胡超群

doi:10.3969/j.issn.1001-5256.2019.10.045

自身免疫性肝炎发病机制的研究现状

DOI: 10.3969/j.issn.1001-5256.2019.10.045

1. 首都医科大学附属北京地坛医院中西医结合一科
2. 北京中医药大学东直门医院

基金项目:

北京市医院管理局临床医学发展专项经费资助(ZYLX201707)；

详细信息

中图分类号: R575.1
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- 被引次数: 0
出版历程
- 收稿日期: 2019-05-20
- 出版日期: 2019-10-20

Research advances in the pathogenesis of autoimmune hepatitis

First Department of Integrated Traditional Chinese and Western Medicine,Beijing Ditan Hospital,Capital Medical University

Research funding:

摘要

摘要: 自身免疫性肝炎是一种病因尚不明确的、进行性的慢性炎症性肝病。目前,遗传易感性和环境因素是普遍公认的自身免疫性肝炎病因学因素。近年来随着研究的不断深入,免疫细胞、免疫因子、肝移植及药物等病因学因素也逐渐受到关注,阐述了近5年的相关最新研究成果。
- 肝炎,自身免疫性 /
- 疾病遗传易感性 /
- 环境因素诱发疾病 /
- 免疫因子类 /
- 化学性与药物性肝损伤 /
- 肝移植
Abstract: Autoimmune hepatitis(AIH) is a progressive chronic inflammatory liver disease with unknown etiology. At present,genetic susceptibility and environmental factors are universally recognized as the etiological factors for AIH. With the deepening of research in recent years,other etiological factors,such as immune cells,immune factors,liver transplantation,and drugs,have attracted more and more attention. This article briefly describes related research findings in the past five years.
- hepatitis,autoimmunity /
- genetic predisposition to disease /
- disorders of environmental origin /
- immunologic factors /
- chemical and drug induced liver injury /
- liver transplantation

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参考文献(50)

[1] LIWINSKI T,SCHRAMM C. Autoimmune hepatitis-update on clinical management in 2017[J]. Clin Res Hepatol Gastroenterol,2017,41(6):617-625.

[2] WALDENSTROM J. Liver,blood proteins and food proteins[J].Dtsch Z Verdau Stoffwechselkr,1952,12(Spec No):113-121.

[3] WEBB GJ,HIRSCHFIELD GM. Using GWAS to identify genetic predisposition in hepatic autoimmunity[J]. J Autoimmun,2016,66:25-39.

[4] de BOER YS,van GERVEN NM,ZWIERS A,et al. Genomewide association study identifies variants associated with autoimmune hepatitis type 1[J]. Gastroenterology,2014,147(2):443-452.

[5] van GERVEN NM,de BOER YS,ZWIERS A,et al. HLADRB1*03∶01 and HLA-DRB1*04∶01 modify the presentation and outcome in autoimmune hepatitis type-1[J]. Genes Immun,2015,16(4):247-252.

[6] BITTENCOURT PL,GOLDBERG AC,CANCADO EL,et al. Genetic heterogeneity in susceptibility to autoimmune hepatitis types1 and 2[J]. Am J Gastroenterol,1999,94(7):1906-1913.

[7] OKA S,FURUKAWA H,YASUNAMI M,et al. HLA-DRB1and DQB1 alleles in Japanese type 1 autoimmune hepatitis:The predisposing role of the DR4/DR8 heterozygous genotype[J]. PLo S One,2017,12(10):e187325.

[8] MA Y,BOGDANOS DP,HUSSAIN MJ,et al. Polyclonal Tcell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2[J]. Gastroenterology,2006,130(3):868-882.

[9] OKA S,HIGUCHI T,FURUKAWA H,et al. Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population[J]. J Hum Genet,2018,63(6):739-744.

[10] ESKANDARI-NASAB E,TAHMASEBI A,HASHEMI M. Meta-analysis:The relationship between CTLA-4+49 A/G polymorphism and primary biliary cirrhosis and type I autoimmune hepatitis[J]. Immunol Invest,2015,44(4):331-348.

[11] CHAOUALI M,AZAIEZ MB,TEZEGHDENTI A,et al. Association of TNF-alpha-308 polymorphism with susceptibility to autoimmune hepatitis in Tunisians[J]. Biochem Genet,2018,56(6):650-662.

[12] XU E,CAO H,LIN L,et al. rs10499194 polymorphism in the tumor necrosis factor-alpha inducible protein 3(TNFAIP3)gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population[J]. PLo S One,2017,12(4):e176471.

[13] HIGUCHI T,OKA S,FURUKAWA H,et al. Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1[J]. J Hum Genet,2017,62(4):481-484.

[14] MIGITA K,JIUCHI Y,FURUKAWA H,et al. Lack of association between the CARD10 rs6000782 polymorphism and type 1autoimmune hepatitis in a Japanese population[J]. BMC Res Notes,2015,8:777.

[15] ASSIS DN,TAKAHASHI H,LENG L,et al. A macrophage migration inhibitory factor polymorphism is associated with autoimmune hepatitis severity in US and Japanese patients[J].Dig Dis Sci,2016,61(12):3506-3512.

[16] CHAOUALI M,FERNANDES V,GHAZOUANI E,et al. Association of STAT4, TGFbeta1, SH2B3 and PTPN22 polymorphisms with autoimmune hepatitis[J]. Exp Mol Pathol,2018,105(3):279-284.

[17] WEBB G,CHEN YY,LI KK,et al. Single-gene association between GATA-2 and autoimmune hepatitis:A novel genetic insight highlighting immunologic pathways to disease[J]. J Hepatol,2016,64(5):1190-1193.

[18] YOUSEFI A,MAHMOUDI E,ZARE BA,et al. IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis[J].Expert Rev Gastroenterol Hepatol,2016,10(5):659-663.

[19] YOUSEFI A,ZARE BA,SHAFIOYOUN A,et al. Association of IL-10 and TGF-beta cytokine gene polymorphisms with autoimmune hepatitis[J]. Clin Res Hepatol Gastroenterol,2019,43(1):45-50.

[20] FLOREANI A,RESTREPO-JIMENEZ P,SECCHI MF,et al.Etiopathogenesis of autoimmune hepatitis[J]. J Autoimmun,2018,95:133-143.

[21] EDER M,STRASSL R,BEINHARDT S,et al. high seroprevalence of anti-hepatitis E antibodies in Austrian patients with autoimmune hepatitis[J]. Liver Int,2019,39(4):640-645.

[22] TERZIROLI BB,RIPELLINO P,GOBBI C,et al. Autoimmune liver disease serology in acute hepatitis E virus infection[J]. J Autoimmun,2018,94:1-6.

[23] PAIARDINI A,PASCARELLA S. Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis:Insights from an in silico study[J]. Theor Biol Med Model,2013,10:25.

[24] CHRISTEN U,HINTERMANN E. Pathogen infection as a possible cause for autoimmune hepatitis[J]. Int Rev Immunol,2014,33(4):296-313.

[25] MA Y,GAKEN J,MCFARLANE BM,et al. Alcohol dehydrogenase:A target of humoral autoimmune response in liver disease[J]. Gastroenterology,1997,112(2):483-492.

[26] NGU JH,GEARRY RB,FRAMPTON CM,et al. Autoimmune hepatitis:The role of environmental risk factors:A population-based study[J]. Hepatol Int,2013,7(3):869-875.

[27] ANAYA JM,RESTREPO-JIMENEZ P,RAMIREZ-SANTANA C. The autoimmune ecology:An update[J]. Curr Opin Rheumatol,2018,30(4):350-360.

[28] CZAJA AJ,MONTANO-LOZA AJ. Evolving role of vitamin D in immune-mediated disease and its implications in autoimmune hepatitis[J]. Dig Dis Sci,2019,64(2):324-344.

[29] LUONG KV,NGUYEN LT. The role of vitamin D in autoimmune hepatitis[J]. J Clin Med Res,2013,5(6):407-415.

[30] EBADI M,BHANJI RA,MAZURAK VC,et al. Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis[J]. Aliment Pharmacol Ther,2019,49(2):173-182.

[31] CAI W,RAN Y,LI Y,et al. Intestinal microbiome and permeability in patients with autoimmune hepatitis[J]. Best Pract Res Clin Gastroenterol,2017,31(6):669-673.

[32] NGO ST,STEYN FJ,MCCOMBE PA. Gender differences in autoimmune disease[J]. Front Neuroendocrinol,2014,35(3):347-369.

[33] SCHWINGE D,SCHRAMM C. Sex-related factors in autoimmune liver diseases[J]. Semin Immunopathol,2019,41(2):165-175.

[34] CASTIELLA A,ZAPATA E,LUCENA MI,et al. Drug-induced autoimmune liver disease:A diagnostic dilemma of an increasingly reported disease[J]. World J Hepatol,2014,6(4):160-168.

[35] DELEMOS AS,FOUREAU DM,JACOBS C,et al. Drug-induced liver injury with autoimmune features[J]. Semin Liver Dis,2014,34(2):194-204.

[36] GAO XQ,ZHAO YX,REN Q,et al. Research advances in drug-induced autoimmune hepatitis[J]. J Clin Hepatol,2017,33(11):2222-2225.(in Chinese)高晓琴,赵永勋,任茜,等.药物诱导的自身免疫性肝炎的研究进展[J].临床肝胆病杂志,2017,33(11):2222-2225.

[37] CZAJA AJ. Transitioning from idiopathic to explainable autoimmune hepatitis[J]. Dig Dis Sci,2015,60(10):2881-2900.

[38] HISAMOCHI A,KAGE M,IDE T,et al. An analysis of druginduced liver injury,which showed histological findings similar to autoimmune hepatitis[J]. J Gastroenterol,2016,51(6):597-607.

[39] de BOER YS,KOSINSKI AS,URBAN TJ,et al. Features of autoimmune hepatitis in patients with drug-induced liver injury[J]. Clin Gastroenterol Hepatol,2017,15(1):103-112.

[40] AVERBUKH LD,WU GY. Role of biologics in the development of autoimmune hepatitis:A review[J]. J Clin Transl Hepatol,2018,6(4):402-409.

[41] NISHIDA N,KUDO M. Liver damage related to immune checkpoint inhibitors[J]. Hepatol Int,2019,13(3):248-252.

[42] LIU YJ,WANG GC. Relationship of MCP-1,chronic hepatic disease and its complications[J/CD]. Chin J Liver Dis:Electr Version,2017,9(4):31-37.(in Chinese)刘英娇,王拱辰.单核细胞趋化蛋白-1与慢性肝病及并其发症的相关性[J/CD].中国肝脏病杂志:电子版,2017,9(4):31-37.

[43] WANG J,IOAN-FACSINAY A,van der VOORT EI,et al. Transient expression of FOXP3 in human activated nonregulatory CD4+T cells[J]. Eur J Immunol,2007,37(1):129-138.

[44] LIU Y,YAN W,YUAN W,et al. Treg/Th17 imbalance is associated with poor autoimmune hepatitis prognosis[J]. Clin Immunol,2019,198:79-88.

[45] PAN J,PAN WT,WU LH. Expression and significance of Th22cells and its functional factor interleukin-22 in mice with autoimmune hepatitis[J]. J Clin Hepatol,2018,34(8):1745-1749.(in Chinese)潘景,潘文婷,吴丽慧.辅助性T淋巴细胞22及其效应因子IL-22在自身免疫性肝炎小鼠模型中的表达及意义[J].临床肝胆病杂志,2018,34(8):1745-1749.

[46] ABE K,TAKAHASHI A,FUJITA M,et al. Interleukin-33/ST2-mediated inflammation plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis[J]. Hepatol Commun,2019,3(5):670-684.

[47] KERKAR N,YANNI G.‘De novo’and ‘recurrent’autoimmune hepatitis after liver transplantation:A comprehensive review[J]. J Autoimmun,2016,66:17-24.

[48] VUKOTIC R,VITALE G,D'ERRICO-GRIGIONI A,et al. De novo autoimmune hepatitis in liver transplant:State-of-the-art review[J]. World J Gastroenterol,2016,22(10):2906-2914.

[49] ENNAIFER R,AVADI H,ROMDHANE H,et al. De novo autoimmune hepatitis following liver transplantation for primary biliary cirrhosis:An unusual cause of late grafts dysfunction[J].Pan Afr Med J,2015,21:2.

[50] CZAJA AJ. Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis[J]. World J Gastroenterol,2016,22(42):9257-9278.

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