血清HBV RNA在慢性乙型肝炎临床管理中的应用价值

廖昊; 王杰; 鲁凤民

doi:10.3969/j.issn.1001-5256.2019.10.003

血清HBV RNA在慢性乙型肝炎临床管理中的应用价值

DOI: 10.3969/j.issn.1001-5256.2019.10.003

1. 北京大学深圳医院深圳北京大学香港科技大学医学中心
2. 北京大学基础医学院病原生物学系暨感染病中心

基金项目:

国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项“十三五”计划(2017ZX10302201)；国家自然科学基金(81672013)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2019-08-01
- 出版日期: 2019-10-20

Application value of serum HBV RNA in clinical management of chronic hepatitis B

Peking University Shenzhen Hospital & Shenzhen PKU-HKUST Medical Center

Research funding:

摘要

摘要: 在我国,HBV感染所致病毒性肝炎、肝硬化、肝细胞癌等仍严重威胁我国公民的健康。积极的抗病毒治疗能够明显延缓肝脏疾病进程、减少终末期肝病的发生,但现有药物很难使患者临床治愈,特别是核苷(酸)类药物往往需要长期用药。新的血清学指标可以进一步优化抗病毒治疗方案,其中血清HBV RNA由肝组织内cccDNA转录,主要是未经或部分逆转录的前基因组RNA及其剪切变异体。总结了血清HBV RNA在HBV感染者血清中的存在形式和来源、影响其水平的因素、与其他血清病毒学指标的相关性、及其与肝组织cccDNA的关系,并评价了其在监测抗病毒疗效和预测停药后病毒反弹发生风险等方面的临床意义。
- 乙型肝炎病毒 /
- RNA /
- DNA,环状 /
- 抗病毒药
Abstract: Viral hepatitis,liver cirrhosis,and hepatocellular carcinoma caused by hepatitis B virus(HBV) infection still threaten the health of people in China. Efficient antiviral therapy can significantly prevent the progression of liver diseases and reduce the incidence rate of end-stage liver disease,but it is very difficult to achieve clinical cure by current drugs,and nucleos(t) ide analogues may require long-term medication. New serological markers can be used for further optimization of antiviral regimens,among which serum HBV RNA is transcribed from covalently closed circular DNA(cccDNA) and is mainly derived from pregenomic RNA and its splice variants with no or partial reverse transcription. This article summarizes the sources and existing forms of serum HBV RNA,the influencing factors for serum HBV RNA level,the correlation between serum HBV RNA and other serum virological markers,and the correlation between serum HBV RNA and cccDNA in liver tissue,as well as the clinical significance of serum HBV RNA in monitoring antiviral efficacy and predicting the risk of viral rebound after drug withdrawal.
- hepatitis B virus /
- RNA /
- DNA,circular /
- antiviral agents

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参考文献(37)

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