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FibroScan对慢性丙型肝炎进展期肝纤维化的诊断价值及其影响因素

仇丽霞 梁珊 范作鹏 马丽霞 韦新焕 郭海清 林伟 刘义荣 于海滨 柳雅立 张晶

引用本文:
Citation:

FibroScan对慢性丙型肝炎进展期肝纤维化的诊断价值及其影响因素

DOI: 10.3969/j.issn.1001-5256.2019.09.013
基金项目: 

首都医学大学附属北京佑安医院院内中青年人才孵育项目(YNKTTS20180114); 

详细信息
  • 中图分类号: R512.63

Value of FibroScan in the diagnosis of progressive liver fibrosis in patients with chronic hepatitis C and related influencing factors

Research funding: 

 

  • 摘要: 目的分析FibroScan对慢性丙型肝炎进展期肝纤维化的诊断效能并探讨其影响因素。方法选取2015年6月-2018年6月于首都医科大学附属北京佑安医院就诊的慢性丙型肝炎患者,均完成肝穿刺病理检查。根据METAVIR评分系统进行纤维化分期,分为F1~F4期。收集患者一般资料,所有患者进行肝脏弹性检测和肝功能、血常规、病毒定量等检测,利用公式计算APRI及FIB-4。不符合正态分布的计量资料多组间比较采用Kruskal-Wallis H秩和检验,进一步两两比较采用Wilcoxon秩和检验。相关性检验采用Spearman秩相关分析。利用受试者工作特征曲线(ROC曲线)分析3种无创诊断方法对肝纤维化的诊断价值,采用STATA验证3种无创诊断方法是否存在统计学差异。结果入组患者共131例,其中男60例(45. 80%),女71例(54. 20%),平均54. 00(45. 00~58. 25)岁。FibroScan水平为7. 80(5. 60~14. 30) kPa,APRI水平为0. 63(0. 37~1. 28),FIB-4水平为2. 28(1. 43~3. 60)。随着肝纤维化分期的进展,...

     

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  • 收稿日期:  2019-05-07
  • 出版日期:  2019-09-20
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