富马酸丙酚替诺福韦治疗慢性乙型肝炎的研究现状

王素娜; 连建奇; 贾战生; 张颖

doi:10.3969/j.issn.1001-5256.2019.08.040

富马酸丙酚替诺福韦治疗慢性乙型肝炎的研究现状

DOI: 10.3969/j.issn.1001-5256.2019.08.040

空军军医大学唐都医院感染病科

基金项目:

国家自然科学基金(81870414)；国家十三五传染病重大专项课题(2018ZX10302-206)；唐都医院创新发展基金资助项目(2017GJHZ001)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2019-04-04
- 出版日期: 2019-08-20

Research advances in the clinical effect of tenofovir alafenamide in treatment of chronic hepatitis B

Department of Infectious Diseases, Tangdu Hospital of Air Force Medical University

Research funding:

摘要

摘要: 富马酸丙酚替诺福韦(TAF)是一种新型的核苷酸逆转录酶抑制剂,用于治疗HIV感染和慢性HBV感染。与富马酸替诺福韦二吡呋酯(TDF)相比,TAF具有更好的血浆稳定性和更强的肝脏靶向性,并且极大的降低了肾功能损伤、骨密度降低等副作用。概述了TAF的药理学特点、代谢途径、药物相互作用、耐药性、肾脏安全性及其在慢性HBV感染者中的最新临床研究进展。
- 乙型肝炎,慢性 /
- 替诺福韦 /
- 富马酸丙酚替诺福韦 /
- 富马酸替诺福韦二吡呋酯 /
- 治疗结果
Abstract: Tenofovir alafenamide (TAF) is a novel nucleoside reverse transcriptase inhibitor used in the treatment of human immunodeficiency virus (HIV) infection and chronic hepatitis B virus (HBV) infection. Compared with tenofovir disoproxil fumarate, TAF has better plasma stability and stronger liver-targeting ability and can significantly reduce the adverse events of renal injury and reduced bone mineral density. This article summarizes the research advances in the pharmacological characteristics, metabolic pathways, drug interactions, drug resistance, and renal safety of TAF and its role in patients with chronic HBV infection.
- hepatitis B, chronic /
- tenofovir /
- tenofovir alafenamide /
- tenofovir disoproxil fumarate /
- treatment outcome

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参考文献(46)

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