HBsAg定量在核苷(酸)类似物个体化抗HBV治疗中的应用价值

周友乾; 李翠

doi:10.3969/j.issn.1001-5256.2019.08.038

HBsAg定量在核苷(酸)类似物个体化抗HBV治疗中的应用价值

DOI: 10.3969/j.issn.1001-5256.2019.08.038

周友乾,
李翠

解放军联勤保障部队第九二二医院暨湖南师范大学附属湘南医院感染科

基金项目:

湖南省卫生计生委课题(C2016096)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2019-02-19
- 出版日期: 2019-08-20

Value of HBsAg quantification in individualized anti-HBV treatment with nucleos (t) ide analogues

Department of Infectious Diseases, 922 Hospital of PLA & Xiangnan Hospital Affiliated to Hunan Normal University

Research funding:

摘要

摘要: 核苷(酸)类似物可有效阻止或延缓慢性HBV感染者的疾病进展,但其疗程长且长期用药存在一定的药物副反应及耐药风险。近期研究发现HBsAg定量对慢性乙型肝炎患者的个体化抗病毒治疗有重要意义。就目前HBsAg定量在核苷(酸)类似物抗HBV治疗的指征评判、疗效预测及停药把握等方面的研究进展进行综述,认为HBsAg定量不仅有利于合理选择抗病毒治疗时机,而且有利于在抗病毒治疗开始时、治疗过程中以及考虑停药时预测患者可能疗效。但是对于HBeAg阳性或阴性感染者各病程分期的最佳预测阈值和不同核苷(酸)类似物抗病毒治疗过程中疗效预测的最佳时间点与最佳预测阈值仍值得进一步研究。
- 乙型肝炎病毒 /
- 乙型肝炎表面抗原 /
- 核苷类 /
- 核苷酸类 /
- 治疗学
Abstract: Nucleos (t) ide analogues can effectively prevent or delay disease progression in patients with chronic hepatitis B virus (HBV) infection, but the course of treatment is long and long-term medication may bring the risk of adverse drug reactions and drug resistance. Recent studies have found that HBsAg quantification has an important value in individualized antiviral treatment for patients with chronic hepatitis B. This article reviews the research advances in the value of HBsAg quantification in judgment of indication for antiviral treatment with nucleos (t) ide analogues, prediction of therapeutic outcome, and timing of drug withdrawal, and it is pointed out that HBsAg quantification can help to determine the timing of antiviral treatment and predict the treatment outcome of patients at the beginning of antiviral treatment, during the treatment process, and when drug withdrawal is considered. Further studies are needed to determine the optimal predictive thresholds for different stages of HBeAg-positive or HBeAg-negative patients, as well as the optimal time point and thresholds for predicting treatment outcome during antiviral treatment with different nucleos (t) ide analogues.
- hepatitis B virus /
- hepatitis B surface antigens /
- nucleosides /
- nucleotides /
- therapeutics

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参考文献(29)

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