microRNA调控肝缺血再灌注损伤的作用机制

张世龙; 彭慈军; 冯赞杰; 高伟东; 段玉灵; 范国鑫

doi:10.3969/j.issn.1001-5256.2019.07.045

microRNA调控肝缺血再灌注损伤的作用机制

DOI: 10.3969/j.issn.1001-5256.2019.07.045

遵义医科大学附属医院肝胆外科
遵义医科大学生物化学与分子生物学教研室

基金项目:

国家自然科学基金(81660688)；贵州省卫计委基金项目(gzwjkj2016-1-035)；

详细信息

中图分类号: R657.3
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出版历程
- 收稿日期: 2019-03-11
- 出版日期: 2019-07-20

Mechanism of action of microRNA in the regulation of hepatic ischemia-reperfusion injury

Department of Hepatobiliary Surgery, The Affiliated Hospital of Zunyi Medical University

Research funding:

摘要

摘要: 肝缺血再灌注损伤是影响临床肝外科手术预后的重要原因之一。研究发现microRNA可通过多条途径参与肝缺血再灌注损伤过程。归纳总结了microRNA的生物合成与功能及其通过能量代谢、凋亡、自噬、氧化应激和细胞炎症等途径调控肝缺血再灌注损伤的相关机制。认为以microRNA为靶点治疗肝缺血再灌注损伤有广阔的应用前景,期待之后更深入的研究。
- 再灌注损伤 /
- 微RNAs /
- 细胞凋亡 /
- 自噬 /
- 炎症
Abstract: Hepatic ischemia-reperfusion injury is one of the most important factors affecting the prognosis of clinical hepatic surgery. Studies have shown that microRNAs can participate in the process of hepatic ischemia-reperfusion injury through multiple pathways. This article reviews the biosynthesis and function of microRNAs and the mechanisms of action of microRNAs in the regulation of hepatic ischemia-reperfusion injury through energy metabolism, apoptosis, autophagy, oxidative stress, and cellular inflammation. It is pointed out that the treatment targeting microRNAs has a promising future in the treatment of hepatic ischemia-reperfusion injury, and further studies are needed in the future.
- reperfusion injury /
- microRNAs /
- apoptosis /
- autophagy /
- inflammation

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参考文献(30)

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