中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

趋化因子与非酒精性脂肪性肝病的相关性

储佩玲 王琦 郭小青 刘近春

引用本文:
Citation:

趋化因子与非酒精性脂肪性肝病的相关性

DOI: 10.3969/j.issn.1001-5256.2019.07.044
基金项目: 

山西省科技成果转化引导专项二批项目(201604D132042); 

详细信息
  • 中图分类号: R575.5

Association between chemokines and nonalcoholic fatty liver disease

Research funding: 

 

  • 摘要: 近年来,非酒精性脂肪性肝病(NAFLD)的发病率持续攀升,发病年龄呈现低龄化趋势,已成为21世纪重大的公共卫生问题之一。综述了近年部分趋化因子(CCL2、CCL5、CXCL8和CXCL10)与NAFLD的相关性研究,以期为NAFLD的发病机制及防治研究提供方向。

     

  • [1]BOUCHRA E.Potential role of chemokines in fracture repair[J].Front Endocrinol (Lausanne) , 2017, 8:39.
    [2]WASMUTH HE, TACKE F, TRAUTWEIN C.Chemokines in liver inflammation and fibrosis[J].Semin Liver Dis, 2010, 30 (3) :215-225.
    [3]FAHEY S, DEMPSEY E, LONG A.The role of chemokines in acute and chronic hepatitis C infection[J].Cell Mol Immunol, 2014, 11 (1) :25-40.
    [4]MARRA F, TACKE F.Roles for chemokines in liver disease[J].Gastroenterology, 2014, 147 (3) :577-594.e1.
    [5]EHOLING J, TACKE F.Role of chemokine pathways in hepatobiliary cancer[J].Cancer Lett, 2016, 379 (2) :173-183.
    [6]EGAN CE, DAUGHERITY EK, ROGERS AB, et al.CCR2 and CD44 promote inflammatory cell recruitment during fatty liver formation in a lithogenic diet fed mouse model[J].PLo S One, 2013, 8 (6) :e65247.
    [7]KIROVSKI G, DORN C, HUBER H, et al.Elevated systemic monocyte chemoattractrant protein-1 in hepatic steatosis without significant hepatic inflammation[J].Exp Mol Pathol, 2011, 91 (3) :780-783.
    [8]SIERRA-FILARDI E, NIETO C, DOMNGUEZ-SOTO A, et al.CCL2 shapes macrophage polarization by GM-CSF and M-CSF:Identification of CCL2/CCR2-dependent gene expression profile[J].Immunol, 2014, 192 (8) :3858-3867.
    [9]BAECK C, WEI X, BARTNECK M, et al.Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C (+) macrophage infiltration in mice[J].Hepatology, 2014, 59 (3) :1060-1072.
    [10]MIURA K, YANG L, van ROOIJEN N, et al.Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2[J].Am J Physiol Gastrointest Liver Physiol, 2012, 302 (11) :g1310-g1321.
    [11]CRANFORD TL, ENOS RT, VELAZQUEZ KT, et al.Role of MCP-1 on inflammatory processes and metabolic dysfunction following high-fat feedings in the FVB/N strain[J].Int JObes (Lond) , 2015, 40 (5) :844-851.
    [12]NIO Y, YAMAUCHI T, IWABU M, et al.Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice[J].Diabetologia, 2012, 55 (12) :3350-3358.
    [13]RICHARD P, WESTON CJ, ZHENHUA M, et al.CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease[J].Am J Physiol Gastrointest Liver Physiol, 2018, 314 (4) :g483-g493.
    [14]ERIC L, GRAEME M, RAN R, et al.Antifibrotic effects of the dual CCR2/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis[J].PLo S One, 2016, 11 (6) :e0158156.
    [15]FRIEDMAN SL, RATZIU V, HARRISON SA, et al.A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis[J].Hepatology, 2018, 67 (5) :1754-1767.
    [16]KOLATTUKUDY PE, NIU J.Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1/CCR2 pathway[J].Circ Res, 2012, 110 (1) :174.
    [17]KIM HM, LEE ES, LEE BR, et al.C-C chemokine receptor 2inhibitor ameliorates hepatic steatosis by improving ER stress and inflammation in a Type 2 diabetic mouse model[J].PLo SOne, 2015, 10 (3) :e0120711.
    [18]GEORGI K, ERWIN G, CHRISTOPH D, et al.Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation[J].Int J Clin Exp Pathol, 2010, 3 (7) :675-680.
    [19]KIM BM, ABDELFATTAH AM, VASAN R, et al.Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis[J].Sci Rep, 2018, 8 (1) :7499.
    [20]WU S, YANO S, HISANAGA A, et al.Polyphenols from Lonicera caerulea L.berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation[J].Mol Nutr Food Res, 2017, 61 (4) :1600858.
    [21]KITADE H, SAWAMOTO K, NAGASHIMADA M, et al.CCR5plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status[J].Diabetes, 2012, 61 (7) :1680-1690.
    [22]HU Y, ZHANG H, LI J, et al.Gut-derived lymphocyte recruitment to liver and induce liver injury in non-alcoholic fatty liver disease mouse model[J].J Gastroenterol Hepatol, 2016, 31 (3) :676-684.
    [23]CASTRO CA, DA SILVA KA, BUFFO MM, et al.Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats[J].Int J Exp Pathol, 2017, 98 (1) :26-33.
    [24]BAHCECIOGLU IH, YALNIZ M, ATASEVEN H, et al.Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitis[J].Hepatogastroenterology, 2005, 52 (65) :1549-1553.
    [25]RUSSO RC, GARCIA CC, TEIXEIRA MM, et al.The CXCL8/IL-8chemokine family and its receptors in inflammatory diseases[J].Expert Rev Clin Immunol, 2014, 10 (5) :593-619.
    [26]CHAVEZ-TAPIA NC, TIRIBELLI C, ROSSO N.Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease[J].BMC Gastroenterol, 2012, 12 (1) :20.
    [27]CENGIZ M, YAASAR DG, ERGUN MA, et al.The role of interleukin-6 and interleukin-8 gene polymorphisms in non-alcoholic steatohepatitis[J].Hepat Mon, 2014, 14 (12) :e24635.
    [28]GLASS O, HENAO R, PATEL K, et al.Serum interleukin-8, osteopontin, and monocyte chemoattractant protein 1 are associated with hepatic fibrosis in patients with nonalcoholic fatty liver disease[J].Hepatol Commun, 2018, 2 (11) :1344-1355.
    [29]YIN Z, HUANG J, MA T, et al.Macrophages activating chemokine (C-X-C motif) ligand 8/miR-17 cluster modulate hepatocellular carcinoma cell growth and metastasis[J].Am JTransl Res, 2017, 9 (5) :2403.
    [30]ZHANG X, HAN J, MAN K, et al.CXC chemokine receptor 3promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy[J].J Hepatol, 2016, 64 (1) :160-170.
    [31]ZHANG X, SHEN J, MAN K, et al.CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis[J].J Hepatol, 2014, 61 (6) :1365-1375.
    [32]ZHANG X, WU WK, XU W, et al.C-X-C motif chemokine 10impairs autophagy and autolysosome formation in non-alcoholic steatohepatitis[J].Theranostics, 2017, 7 (11) :2822-2836.
    [33]JINGHUA D, XIANG Z, JUQIANNG H, et al.Pro-inflammatory CXCR3 impairs mitochondrial function in experimental non-alcoholic steatohepatitis[J].Theranostics, 2017, 7 (17) :4192-4203.
    [34]ZEREMSKI M, PETROVIC LM, CHIRIBOGA L, et al.Intrahepatic levels of cxcr3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C[J].Hepatology, 2008, 48 (5) :1440-1450.
    [35]WADA N, TAKAKI A, IKEDA F, et al.Serum-inducible protein (IP) -10 is a disease progression-related marker for non-alcoholic fatty liver disease[J].Hepatol Int, 2017, 11 (1) :115-124.
    [36]WOLFS MG, GRUBEN N, RENSEN SS, et al.Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity[J].Nutr Diabetes, 2015, 5 (2) :e146.
    [37]TOMITA K, NIIBE A, FRREEMAN BL, et al.Mixed lineage kinase 3 mediates the induction of CXCL10 by a STAT1-dependent mechanism during hepatocyte lipotoxicity[J].J Cell Biochem, 2017, 118 (10) :3249-3259.
    [38]TOMITA K, KOHLI R, MACLAURIN BL, et al.Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis[J].JCI Insight, 2017, 2 (15) .pii:94488.
  • 加载中
计量
  • 文章访问数:  1152
  • HTML全文浏览量:  31
  • PDF下载量:  251
  • 被引次数: 0
出版历程
  • 收稿日期:  2019-01-09
  • 出版日期:  2019-07-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回