IgG4相关性肝胆胰疾病的发病机制

张德华; 赵婕

doi:10.3969/j.issn.1001-5256.2019.06.050

IgG4相关性肝胆胰疾病的发病机制

DOI: 10.3969/j.issn.1001-5256.2019.06.050

张德华,
赵婕

详细信息

中图分类号: R576;R575
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- 文章访问数: 399
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- 被引次数: 0
出版历程
- 收稿日期: 2018-12-12
- 出版日期: 2019-06-20

Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases

摘要

摘要: IgG4相关性疾病（IgG4-RD）是一种可累及全身的多系统的慢性进行性自身免疫性疾病,IgG4相关性肝胆胰疾病为IgG4-RD受累肝胆胰腺系统表现,其主要特征为血清IgG4水平升高和IgG4阳性淋巴浆细胞浸润,可模仿各种炎症及肿瘤疾病,临床易漏诊误诊。从基因遗传、感染与分子模拟、免疫因素等方面阐述IgG4相关性肝胆胰疾病的发病机制,从而提高对该病的认识。
- 免疫球蛋白G /
- 自身免疫疾病 /
- 胰腺炎 /
- 胆管炎,硬化性 /
- 肝疾病 /
- 综述
Abstract: Immunoglobulin G4 (IgG4) -related disease is a chronic progressive autoimmune disease involving multiple systems throughout the body. IgG4-related hepatobiliary and pancreatic diseases are the manifestation of IgG4-related disease involving the hepatobiliary and pancreatic systems, with the main features of an increased serum IgG4 level and IgG4-positive lymphoplasmacytic infiltration. IgG4-related hepatobiliary and pancreatic diseases can mimic various inflammations and tumor diseases, which may lead to missed diagnosis and misdiagnosis in clinical practice. This article elaborates on the pathogenesis of IgG4-related hepatobiliary and pancreatic diseases from the perspectives of genetic inheritance, infection and molecular mimicry, and immune factors, so as to improve the understanding of such diseases.
- immunoglobulin G /
- autoimmune diseases /
- pancreatitis /
- cholangitis, sclerosing /
- liver diseases /
- review

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参考文献(63)

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