Th1/Th2细胞平衡与纤维增生性疾病的相关性

黄辉; 周扬; 平键; 徐列明

doi:10.3969/j.issn.1001-5256.2019.04.039

Th1/Th2细胞平衡与纤维增生性疾病的相关性

DOI: 10.3969/j.issn.1001-5256.2019.04.039

1. 上海中医药大学附属曙光医院
2. 上海中医药大学肝病研究所
3. 上海中医药大学附属岳阳医院
4. 肝肾疾病病证教育部重点实验室

基金项目:

国家自然科学基金资助项目(8157141178)；

详细信息

中图分类号: R364
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出版历程
- 出版日期: 2019-04-20

Research advances in Th1/Th2 balance and fibrotic diseases

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 机体免疫与纤维化疾病的发生存在密切联系。其中CD4+T淋巴细胞亚群的辅助性T淋巴细胞（Th） 1/Th2之间的细胞平衡在许多疾病的发生与发展中发挥着重要的调节作用。介绍了Th1/Th2细胞平衡与肝纤维化、肺纤维化及肾纤维化之间的相关性。认为除对Th1/Th2分泌的细胞因子检测外,还应对Th与其他细胞之间的具体关系及机制进行研究。
- Th1细胞 /
- Th2细胞 /
- 细胞平衡 /
- 纤维化 /
- 综述
Abstract: Body immunity is closely associated with the pathogenesis of fibrotic diseases. In CD4+ T lymphocyte subsets, T helper 1 ( Th1) /T helper 2 ( Th2) balance plays an important regulatory role in the development and progression of many diseases. This article describes the association of Th1/Th2 balance with liver fibrosis, pulmonary fibrosis, and renal fibrosis. It is believed that in addition to the measurement of single cytokines, further studies are needed to clarify the specific association between T helper cells and other cells and related mechanisms.
- Th1 cells /
- Th2 cells /
- cell balance /
- fibrosis /
- review

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参考文献(29)

[1]MOJIRIFORUSHANI H, HEMMATI A A, KHODADADI A, et al.Valsartan attenuates bleomycin-induced pulmonary fibrosis by inhibition of NF-κB expression and regulation of Th1/Th2cytokines[J]. Data in Brief, 2018, 15 (1) :155-159.

[2]CHAKIR H, WANG H, LEFEBVRE DE, et al. T-bet/GATA-3ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations:Predominant role of GATA-3[J]. J Immunol Methods, 2003, 278 (1-2) :157-169.

[3]LONDON CA, ABBAS AK, KELSO A. Helper T cell subsets:Heterogeneity, functions and development[J]. Vet Immunol Immunopathol, 1998, 63 (1-2) :37-44.

[4]ZHU J, YAMANE H, COTE-SIERRA J, et al. GATA-3 promotes Th2 responses through three different mechanisms:induction of Th2 cytokine production, selective growth of Th2cells and inhibition of Th1 cell-specific factors[J]. Cell Res, 2006, 16 (1) :3-10.

[5]XU AJ, XUE JY, YU SY, et al. The correlation of serum TGF-β1 content with liver fibrosis and Th1/Th2 immune levels in patients with chronic hepatitis B[J]. J Hanan Med Coll, 2018, 24 (2) :195-197. (in Chinese) 徐爱静, 薛建亚, 余思雨, 等.慢性乙肝患者血清TGF-β1含量检测及与肝纤维化、Th1/Th2免疫水平的相关关系[J].海南医学院学报, 2018, 24 (2) :195-197.

[6]CAI X, ZHENG W, PAN S, et al. A virus-like particle of the hepatitis B virus preS antigen elicits robust neutralizing antibody and T cell responses in mice[J]. Antiviral Res, 2017, 149:48-57.

[7]AOUDJEHANE L, BISCH G, SCATTON O, et al. Infection of human liver myofibroblasts by hepatitis C virus:A direct mechanism of liver fibrosis in hepatitis C[J]. PLo S One, 2015, 10 (7) :e0134141.

[8]WU ZD, LIN J, CHU FY, et al. Analysis of peripheral blood T lymphocyte subsets and Th1/Th2 cell factors among patients infected with chronic hepatitis C[J]. Jiangsu J Prevent Med, 2016, 27 (6) :657-659. (in Chinese) 吴志丹, 林江, 褚福营.慢性丙肝患者外周血T淋巴细胞亚群及Th1/Th2细胞因子的分析[J].江苏预防医学, 2016, 27 (6) :657-659.

[9]ZHANG ZH, HAN HX, CAO XD, et al. Preliminary study on the early cellular immune response of the spleen to schistosoma japonicum infection in mice[J]. Chin Vet Sci, 2017, 47 (2) :157-164. (in Chinese) 张祖航, 韩宏晓, 曹晓丹, 等.小鼠抗日本血吸虫感染的脾早期细胞免疫应答的初步研究[J].中国兽医科学, 2017, 47 (2) :157-164.

[10]FARWA A, HE C, XIA L, et al. Immune modulation of Th1, Th2, and T-reg transcriptional factors differing from cytokine levels in Schistosoma japonicum infection[J]. Parasitol Res, 2018, 117 (1) :115-126.

[11]BAI G, YAN G, WANG G, et al. Anti-hepatic fibrosis effects of a novel turtle shell decoction by inhibiting hepatic stellate cell proliferation and blocking TGF-β1/Smad signaling pathway in rats[J]. Oncol Rep, 2016, 36 (5) :2902.

[12]LEWIS F. Schistosomiasis[J]. Adv Exp Med Biol, 2014, 766 (6) :47.

[13]CAI P, PIAO X, LIU S, et al. MicroRNA-gene expression network in murine liver during schistosoma japonicum infection[J]. PLo S One, 2013, 8 (6) :e67037.

[14]TANABE K, TAURA K. Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice[J]. J Gastroenterol, 2015, 50 (10) :1054-1068.

[15]PAUL WE, ZHU JF. How are T (H) 2-type immune responses initiated and amplified?[J]. Nat Rev Immunol, 2010, 10 (4) :225-235.

[16]PENG JK, LIN JS, KUNG JT, et al. The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of type-1 T cells in histoplasma infection[J]. Int Immunol, 2010, 17 (2) :193-205.

[17]CHI G, FENG XX, RU YX, et al. TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression[J]. Mol Immunol, 2018, 99:171-181.

[18]LI J, LI C, ZHENG QH, et al. Study of pulmonary serum Th1/Th2 cytokines in silicosis rats[J]. Chin J Industrial Med, 2014, 27 (4) :291-293. (in Chinese) 李娟, 李超, 郑全辉, 等.矽肺大鼠血清中Th1/Th2类细胞因子的研究[J].中国工业医学杂志, 2014, 27 (4) :291-293.

[19]NEAL LM, QIU Y, CHUNG J, et al. T cell-restricted notch signaling contributes to pulmonary Th1 and Th2 immunity during cryptococcus neoformansInfection.[J]. J Immunol, 2017, 199 (2) :ji1601715.

[20]TU LL, FANG TC, ARTIS D, et al. Notch signaling is an important regulator of type 2 immunity[J]. J Exp Med, 2005, 202 (8) :1037-1042.

[21]CAO H, ZHOU X, ZHANG J, et al. Hydrogen sulfide protects against bleomycin-induced pulmonary fibrosis in rats by inhibiting NF-κB expression and regulating Th1/Th2 balance[J]. Toxicol Lett, 2014, 224 (3) :387-394.

[22]DENG RQ, CHENG JT, ZHANG HH, et al. Effects of emodin on the balance of Th1/Th2 cytokines in pulmonary fibrosis ratsa[J]. J Gannan Med Uni, 2016, 36 (3) :350-354. (in Chinese) 邓日强, 程江涛, 张宏华, 等.大黄素对肺纤维化大鼠Th1/Th2型细胞因子平衡的影响[J].赣南医学院学报, 2016, 36 (3) :350-354.

[23]KIKUCHI N, ISHII Y, MORISHIMA Y, et al. Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance[J]. Respir Res, 2010, 11 (1) :31-31.

[24]LIU L, KOU P, ZENG Q, et al. CD4+T Lymphocytes, especially Th2 cells, contribute to the progress of renal fibrosis[J].Am J Nephrol, 2012, 36 (4) :386-396.

[25]ZHANG YM, ZHANG H. Update on treatment of immunoglobulin a nephropathy[J]. Nephrology (Carlton) , 2018, 23 (Suppl 4) :62-67.

[26]SALLUSTIO F, SERINO G, COX SN, et al. Aberrantly methylated DNA regions lead to low activation of CD4+T cells in IgA nephropathy[J]. Clin Sci, 2016, 130 (9) :733.

[27]INOSHITA H, KIM BG, YAMASHITA M, et al. Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations[J]. PLo S One, 2013, 8 (11) :e78736.

[28]LAI KN, HO RT, LAI CK, et al. Increase of both circulating Th1 and Th2 T lymphocyte subsets in IgA nephropathy[J].Clin Exp Immunol, 2010, 96 (1) :116-121.

[29]SCIVITTARO V, RANIERI E, di CILLO M, et al. In vitro immunoglobulin production in relatives of patients with IgA nephropathy[J]. Clin Nephrol, 1994, 42 (1) :1-8.

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