HBeAg阴性乙型肝炎与前C/BCP区变异的相关性

戴海梅; 韦嘉

doi:10.3969/j.issn.1001-5256.2019.04.038

HBeAg阴性乙型肝炎与前C/BCP区变异的相关性

DOI: 10.3969/j.issn.1001-5256.2019.04.038

戴海梅,
韦嘉

1. 昆明医科大学
2. 昆明医科大学第四附属医院感染-肝病科

基金项目:

云南省第二人民医院病毒性肝炎及相关肝病研究省创新团队项目(2015HC019)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2019-04-20

Association between HBeAg-negative chronic hepatitis B and pre C/BCP mutation

Dai HaiMei,
Wei Jia

Kunming Medical University

Research funding:

摘要

摘要: 通过对HBV基因的研究表明,HBeAg阴性慢性乙型肝炎(CHB)与HBV DNA中前C(PC)、基本核心启动子(BCP)区的基因突变相关,并指出PC/BCP区的突变不仅影响血清HBeAg的表达,也与机体内HBV DNA的低复制、疾病的进展和抗病毒治疗的应答反应密切相关,使得CHB的治疗变得更为复杂。就HBeAg阴性CHB目前治疗现状、HBV PC/BCP区基因的结构与变异、变异对HBeAg阴性CHB疾病进展以及对乙型肝炎抗病毒治疗的影响进行综述。
- 肝炎,乙型,慢性 /
- 突变 /
- 肝炎e抗原,乙型 /
- 综述
Abstract: Studies on the HBV gene have shown that HBeAg-negative chronic hepatitis B ( CHB) is associated with gene mutations in the pre-C ( preC) and basic core promoter ( BCP) region of HBV DNA, and it is pointed out that the mutation in the preC/BCP region can affect the expression of serum HBeAg and is closely associated with the low replication of HBV DNA in the body, the progression of diseases, and the response to antiviral therapy, which makes the treatment of CHB more complicated. This article reviews the current status of the treatment of HBeAg-negative CHB, structure and mutation of HBV preC/BCP region, and the influence of mutation on the progression of HBeAg-negative CHB and the effect of antiviral therapy for hepatitis B.
- hepatitis B, chronic /
- mutation /
- hepatitis B e antigens /
- review

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参考文献(38)

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