肝硬化患者血清CA125水平与肝损害程度相关性的Meta分析

邵翠萍; 徐有青

doi:10.3969/j.issn.1001-5256.2019.04.018

肝硬化患者血清CA125水平与肝损害程度相关性的Meta分析

DOI: 10.3969/j.issn.1001-5256.2019.04.018

首都医科大学附属北京天坛医院消化内科

基金项目:

国家科技重大专项课题(2018ZX10302204)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2019-04-20

Correlation between serum CA125 level and severity of liver dysfunction in patients with liver cirrhosis: A Meta-analysis

Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University

Research funding:

摘要

摘要: 目的探讨肝硬化患者血清CA125与肝功能损害程度的关系。方法检索万方科技期刊全文数据库、中国学术期刊（CNKI）全文数据库、中国生物医学文献数据库（CBM）、维普（VIP）中文科技期刊全文数据库于2008年1月-2018年10月发表的有关CA125与肝硬化患者肝损害程度相关性的中文文献,每篇文献均需设立肝硬化组及正常对照组。采用观察性流行病学研究报告规范（STROBE）为参考标准来评价入选文献质量。合并各文献肝硬化组和健康对照组、肝硬化组各Child-Pugh分级组CA125均数及标准差。采用Meta-Analyst软件计算文献中各组CA125标准化均值差（SMD）进行Meta分析,对纳入的各研究进行异质性分析,如果各研究间存在显著异质性,则采用随机效应模型进行分析;如果各研究间异质性不显著,则采用固定效应模型进行分析。计量资料多组间比较采用单因素方差分析。结果共有15篇文献纳入研究。Meta分析结果显示,肝硬化组CA125水平显著高于健康对照组[（181. 18±110. 76） U/ml vs （15. 10±7. 15） U/ml],差异有统计学意义（SMD=2. 28,95%可...
- 肝硬化 /
- CA-125抗原 /
- Child-Pugh分级 /
- Meta分析
Abstract: Objective To investigate the correlation between serum CA125 level and the severity of liver dysfunction in patients with liver cirrhosis. Methods Wanfang Data, CNKI, CBM, and VIP were searched for Chinese articles on the correlation between serum CA125 level and the severity of liver dysfunction in patients with liver cirrhosis published from January, 2008 to October, 2018, with a liver cirrhosis group and a normal control group in each article. Strengthening the Reporting of Observational Studies in Epidemiology ( STROBE) was used for quality assessment. The mean and standard deviation of CA125 in liver cirrhosis group, healthy control group, and liver cirrhosis groups with different Child-Pugh classes were analyzed. Meta-Analyst software was used to calculate the standardized mean deviation ( SMD) of CA125 in each group and perform the meta-analysis. A heterogeneity analysis was performed for the studies included in this study; a random effects model was used in case of significant heterogeneity, while a fixed effect model was used in case of insignificant heterogeneity. A one-way analysis of variance was used for comparison of continuous data between multiple groups. Results A total of 15 articles were included in this study. The meta-analysis showed that the liver cirrhosis group had a significantly higher serum CA125 level than the healthy control group ( 181. 18 ± 110. 76 U/ml vs 15. 10 ± 7. 15 U/ml, SMD = 2. 28, 95% confidence interval: 1. 81-2. 76, P < 0. 001) . The level of CA125 increased significantly with the increase in Child-Pugh class ( F = 15. 704, P < 0. 001) . Conclusion Serum CA125 level is correlated with the severity of liver dysfunction in patients with liver cirrhosis and thus has a certain value in evaluating the severity of liver dysfunction and predicting prognosis.
- liver cirrhosis /
- CA-125 antigen /
- Child-Pugh grading /
- Meta-analysis

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参考文献(27)

[1]BAST RC, FEENEY M, LAZARUS H, et al. Reactivity of a monoclonal antibody with human ovarian carcinoma[J]. J Clin Invest, 1981, 68 (5) :1331-1337.

[2]SUN CD, SUN G, GUO MZ, et al. Clinical significance and related factors of the serum level of CA125 in liver cirrhosis patients[J]. Chin J Gastroenterol Hepatol, 2014, 23 (5) :501-505. (in Chinese) 孙成都, 孙刚, 郭明洲, 等.血清CA125在肝硬化患者中的临床意义及相关因素研究[J].胃肠病学和肝病学杂志, 2014, 23 (5) :501-505.

[3]CHOI WI, QAMA D, LEE MY, et al. Pleural cancer antigen-125 levels in benign and malignant pleural effusions[J]. Int J Tuberc Lung Dis, 2013, 17 (5) :693-697.

[4]GHADERI B, MOGHBEL H, DANESHKHAH N, et al. Clinical evaluation of serum tumor markers in the diagnosis of gastric adenocarcinoma staging and grading[J]. J Gastrointest Cancer, 2018.[Epub ahead of print]

[5]LU JG. The value of serum carbohydrate antigen CA125 in the diagnosis of benign and malignant diseases[J]. Labeled Immunoassays&Clin Med, 2011, 18 (6) :427-428. (in Chinese) 陆俊钢.血清糖类抗原CA125在良、恶性疾病诊断中的价值和分析[J].标记免疫分析与临床, 2011, 18 (6) :427-428.

[6]EDULA RG, MUTHUKURU S, MOROIANU S, et al. CA-125significance in cirrhosis and correlation with disease severity and portal hypertension:A retrospective study[J]. J Clin Transl Hepatol, 2018, 6 (3) :241-246.

[7]GAO Y, WANG G. Significance of serum CA125 detection in patients with liver cirrhosis[J]. Contemp Med Forum, 2017, 15 (19) :204-205. (in Chinese) 郜燕, 汪刚.对肝硬化患者进行血清CA125检测的临床意义[J].当代医药论丛, 2017, 15 (19) :204-205.

[8]LIU HB. Detection of serum CA125 in patients with liver cirrhosis[J]. National Med Front China, 2010, 5 (10) :59. (in Chinese) 刘红彬.肝硬化患者血清CA125检测[J].中国医疗前沿, 2010, 5 (10) :59.

[9]HUANG XM, QIU JG, HONG RK. Correlation analysis of serum CA125 level between Child-Pugh classification, CHE and volume of ascites in patients with cirrhosis[J]. J Hepatopancreatobiliary Surg, 2016, 28 (1) :13-16. (in Chinese) 黄喜岷, 邱建国, 洪睿珂.肝硬化患者血清CA125水平与ChildPugh分级、CHE及腹水量相关性分析[J].肝胆胰外科杂志, 2016, 28 (1) :13-16.

[10]LI L, ZHOU GZ, LYU J, et al. Relationship between the classification of cirrhosis and the level of serum CA125[J]. J Navy Med, 2010, 31 (1) :15-17. (in Chinese) 李琳, 周国中, 吕礁, 等.肝硬化分级与血清CA125水平变化的关系[J].海军医学杂志, 2010, 31 (1) :15-17.

[11]WANG MY, HE F, HU JG, et al. The clinic significance of serum CA125 level in patients with hepatocirrhosis[J]. J Ningxia Med Coll, 2008, 30 (3) :314-315, 329. (in Chinese) 王明友, 何芳, 胡建国, 等.肝硬化血清CA125测定的临床意义[J].宁夏医学院学报, 2008, 30 (3) :314-315, 329.

[12]ZHANG LG, GAO FZ, CHU RH, et al. The analysis oil the change of serum CA125 level in patients with cirrhotic ascites[J]. Acta Acad Med Weifang, 2010, 32 (3) :219-220. (in Chinese) 张乐刚, 高风至, 褚瑞海, 等.肝硬化腹水患者血清CA125水平的变化分析[J].潍坊医学院学报, 2010, 32 (3) :219-220.

[13]LI KK, ZHAO YB. Clinical significance of serum CA125 and TBA levels in patients with liver cirrhosis[J]. China Foreign Med Treatment, 2011, 30 (10) :35, 37. (in Chinese) 李琨琨, 赵雅彬.肝硬化患者血清CA125及TBA水平变化的临床意义[J].中外医疗, 2011, 30 (10) :35, 37.

[14]CHEN HS, FAN WH. The relationship between the changes of prothrombinⅢand CA125 levels and different Child-Pugh grades in patients with liver cirrhosis[J]. Guangdong Med J, 2015, 36 (19) :3001-3003. (in Chinese) 陈海生, 范婉华.抗凝血酶原Ⅲ及CA125水平变化与肝硬化患者不同Child-Pugh分级的关系[J].广东医学, 2015, 36 (19) :3001-3003.

[15]XU QF, ZENG JG. Clinical study on determination of serum CA125 in patients with liver cirrhosis[J]. Lab Med Clin, 2012, 9 (1) :55, 112. (in Chinese) 徐群芳, 曾贱高.肝硬化患者血清中CA125测定的临床研究[J].检验医学与临床, 2012, 9 (1) :55, 112.

[16]ZHANG DH, WANG S. Clinical evaluation of the level of serum CA125 for hepatic function lesion in patients with cirrhosis[J].J Med Res, 2009, 38 (7) :100-101. (in Chinese) 张东海, 王树.血清CA125水平变化对肝硬化患者的肝功能损害临床评价[J].医学研究杂志, 2009, 38 (7) :100-101.

[17]PAN Q. Clinical significance of serum CA125 detection in the evaluation of liver function damage in patients with liver cirrhosis[J]. China Med Eng, 2013, 12 (21) :145-147. (in Chinese) 潘晴.血清CA125检测在肝硬化患者肝功能损害评价中的临床意义[J].中国医学工程, 2013, 12 (21) :145-147.

[18]HE SF, LI XH, LI YZ, et al. Serum Ca125, Ca199, total bile acid and cholinesterase level and correlation analysis in patients with liver cirrhosis[J]. Med Lab Sci Clin, 2013, 24 (1) :27-28. (in Chinese) 何淑妃, 利旭辉, 李远珍, 等.肝硬化患者血清Ca125、Ca199、总胆汁酸、胆碱酯酶水平及相关性分析[J].医学检验与临床, 2013, 24 (1) :27-28.

[19]JIA YH, LIU SY, DING X. Serum levels of CA125, total bile acid and cholinesterase in patients with liver cirrhosis and their correlation[J]. Guangdong Med J, 2011, 32 (20) :2712-2713. (in Chinese) 贾艳会, 刘树业, 丁贤.肝硬化患者血清CA125、总胆汁酸和胆碱酯酶的水平及其相关性[J].广东医学, 2011, 32 (20) :2712-2713.

[20]LI RH, WU LG. Diagnostic value and clinical significance of serum CA125 in patients with liver cirrhosis[J]. J Clin Med Pract, 2014, 18 (16) :162-163. (in Chinese) 李仁华, 吴立广.血清CA125在肝硬化患者中的诊断价值和临床意义[J].实用临床医药杂志, 2014, 18 (16) :162-163.

[21]XING ZH, TIAN M, YU G, et al. Clinical value of biomarker level subject working characteristic curve in evaluating the severity of liver cirrhosis[J]. Chin J Hemorrheol, 2014, 24 (3) :447-448, 463. (in Chinese) 邢正皓, 田梅, 俞刚, 等.生物标记物水平受试者工作特征曲线评估肝硬化严重程度的临床价值[J].中国血液流变学杂志, 2014, 24 (3) :447-448, 463.

[22]RUAN LS, XU CX, CHEN SY, et al. Significance of CA19-9and CA125 in serum and peritoneal effusion of patients with liver cirrhosis[J]. J Radioimmunol, 2011, 24 (1) :107-108. (in Chinese) 阮林松, 许成新, 陈世勇, 等.肝硬化患者血清及腹腔积液CA19-9、CA125检测的意义[J].放射免疫学杂志, 2011, 24 (1) :107-108.

[23]KALAMBOKIS G, KOSTOULA A, ECONOMOU M, et al. Tumor necrosis factor-alpha-related intraperitoneal release of CA 125in cirrhotic patients with sterile ascites[J]. Clin Chem, 2005, 51 (11) :2207-2208.

[24]JABLKOWSKI M, BIALKOWSKA J, KOKTYSZ R, et al. Cancer antigen 125 as a marker of ascites in patients with liver cirrhosis[J]. Pol Merkur Lekarski, 2004, 17 (Suppl 1) :149-152.

[25]XIAO WB, LIU YL. Elevation of serum and ascites CA125 levels in liver cirrhosis[J]. World Chin J Digestol, 2003, 11 (11) :1720-1722. (in Chinese) 肖文斌, 刘玉兰.肝硬化患者血清和腹水CA125升高[J].世界华人消化杂志, 2003, 11 (11) :1720-1722.

[26]SCHONIGER-HEKELE M, MULLER C. The combined elevation of tumor markers CA 19-9 and CA 125 in liver disease patients is highly specific for severe liver fibrosis[J]. Dig Dis Sci, 2006, 51 (2) :338-345.

[27]XIE WC, ZHANG FF. Variety of serum CA125 level in patients with liver cirrhosis[J]. Clin J Med Offic, 2008, 36 (2) :227-228. (in Chinese) 谢万昌, 章菲菲.肝硬化患者检测血清CA125的临床意义[J].临床军医杂志, 2008, 36 (2) :227-228.

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