高迁移率族蛋白B1与肝缺血再灌注损伤的关系

高伟东; 冯赞杰; 彭慈军; 李阳; 吴波; 耿新

doi:10.3969/j.issn.1001-5256.2019.03.049

高迁移率族蛋白B1与肝缺血再灌注损伤的关系

DOI: 10.3969/j.issn.1001-5256.2019.03.049

1. 遵义医学院附属医院肝胆外科
2. 遵义医学院生物化学与分子生物学教研室

基金项目:

国家自然科学基金(81660688)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2019-03-20

Association between high-mobility group box B1 and hepatic ischemia-reperfusion injury

Department of Hepatobiliary Surgery, The Affiliated Hospital of Zunyi Medical College

Research funding:

摘要

摘要: 高迁移率族蛋白B1(HMGB1)是一种广泛分布于真核细胞中的DNA结合蛋白。当组织损伤时,HMGB1作为内源性危险信号激活机体免疫系统,介导无菌炎症反应。目前已发现其在肝脏缺血再灌注损伤中发挥关键作用。归纳了近年HMGB1在肝缺血再灌注中如何发挥促炎作用以及以HMGB1为靶点治疗肝缺血再灌注损伤的研究进展。
- HMGB蛋白质类 /
- 肝疾病 /
- 缺血 /
- 再灌注损伤 /
- 综述
Abstract: High-mobility group box B1 ( HMGB1) is a DNA-binding protein widely distributed in eukaryotic cells. When tissue damageoccurs, HMGB1 acts as an endogenous risk signal to activate the body's immune system and mediate aseptic inflammatory response. Currentresearch findings have shown that HMGB1 plays a key role in hepatic ischemia-reperfusion injury. This article summarizes the recent re-search advances in the proinflammatory role of HMGB1 in hepatic ischemia-reperfusion and HMGB1 as a target for the treatment of hepaticischemia-reperfusion injury.
- HMGB proteins /
- liver diseases /
- ischemia /
- reperfusion injury /
- review

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参考文献(26)

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