上皮-间质转化相关长链非编码RNA在肝癌中的生物学功能及调控机制

王元; 郭涛; 李靖华; 赵继森; 周元龙; 杨季红

doi:10.3969/j.issn.1001-5256.2019.03.046

上皮-间质转化相关长链非编码RNA在肝癌中的生物学功能及调控机制

DOI: 10.3969/j.issn.1001-5256.2019.03.046

河北大学附属医院肝胆外科

基金项目:

河北省政府资助临床医学优秀人才培养和基础课题研究项目计划(冀财社〔2017〕46号)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2018-11-13
- 出版日期: 2019-03-20

Biological function and regulatory mechanism of epithelial-mesenchymal transition-related long non-coding RNAs in liver cancer

Department of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University

Research funding:

摘要

摘要: 肝癌恶性程度较高,许多癌基因及抑癌基因在肝癌发生发展过程中发挥重要的调控作用。细胞由上皮表型向间质表型转化的过程称为上皮-间质转化（EMT）,可以增加肿瘤细胞迁移侵袭能力,长链非编码RNA能够通过多种方式调控EMT过程。综述了EMT相关长链非编码RNA在肝癌中的主要生物学功能以及调控机制的研究进展。
- 肝肿瘤 /
- 癌基因 /
- 长链非编码RNA /
- 上皮细胞 /
- 间质细胞 /
- 细胞转化,肿瘤 /
- 综述
Abstract: Liver cancer has a high degree of malignancy, and many oncogenes and tumor suppressor genes play an important regulatory rolein the development and progression of liver cancer. Epithelial-mesenchymal transition ( EMT) is a biological process in which epithelialcells transform into mesenchymal cells, which can increase the migration and invasion abilities of tumor cells. Long non-coding RNAs ( ln-cRNAs) can regulate EMT process in various ways. This article reviews the research advances in the main biological functions and regulatorymechanisms of EMT-related lncRNAs in liver cancer.
- liver neoplasms /
- oncogenes /
- lncRNA /
- epithelial cells /
- stromal cells /
- cell transformation, neoplastic /
- review

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参考文献(47)

[1] HAN ZG. Functional genomic studies:Insights into the patho-genesis of liver cancer[J]. Annu Rev Genomics Hum Genet, 2012, 13 (1) :171-205.

[2] XUEFEI S, MING S, HONGBING L, et al. Long non-codingRNAs:A new frontier in the study of human diseases[J].Cancer Lett, 2013, 339 (2) :159-166.

[3] BRANNAN CI, DEES EC, INGRAM RS, et al. The product ofthe H19 gene may function as an RNA[J]. Mol Cell Biol, 1990, 10 (1) :28-36.

[4] LIPOVICH L, JOHNSON R, LIN CY. MacroRNA underdogs ina microRNA world:Evolutionary, regulatory, and biomedicalsignificance of mammalian long non-protein-coding RNA[J]. Biochim Biophys Acta, 2010, 1799 (9) :597-615.

[5] PONTING CP, OLIVER PL, REIK W. Evolution and functions oflong noncoding RNAs[J]. Cell, 2009, 136 (4) :629-641.

[6] KUTTER C, WATT S, STEFFLOVA K, et al. Rapid turnover oflong noncoding RNAs and the evolution of gene expression[J]. PLo S Genet, 2012, 8 (7) :e1002841.

[7] HUNG T, CHANG HY. Long noncoding RNA in genome regu-lation:Prospects and mechanisms[J]. RNA Biol, 2010, 7 (5) :582-585.

[8] LI CH, CHEN Y. Targeting long non-coding RNAs in canc-ers:Progress and prospects[J]. Int J Biochem Cell Biol, 2013, 45 (8) :1895-1910.

[9] ZHANG X, RICE K, WANG Y, et al. Maternally expressedgene 3 (MEG3) noncoding ribonucleic acid:Isoform struc-ture, expression, and functions[J]. Endocrinology, 2010, 151 (3) :939.

[10] LIN R, MAEDA S, LIU C, et al. A large noncoding RNA is amarker for murine hepatocellular carcinomas and a spectrumof human carcinomas[J]. Oncogene, 2007, 26 (6) :851.

[11] HMMERLE M, GUTSCHNER T, UCKELMANN H, et al. Post-transcriptional destabilization of the liver-specific long non-coding RNA HULC, by the IGF2 mRNA-binding protein 1 (IGF2BP1) [J]. Hepatology, 2013, 58 (5) :1703-1712.

[12] FRANCOZORRILLA JM, VALLI A, TODESCO M, et al. Targetmimicry provides a new mechanism for regulation of microRNAactivity[J]. Nat Gene, 2007, 39 (8) :1033-1037.

[13] YANG F, ZHANG L, HUO XS, et al. Long noncoding RNAhigh expression in hepatocellular carcinoma facilitates tumorgrowth through enhancer of zeste homolog 2 in humans[J].Hepatology, 2011, 54 (5) :1679-1689.

[14] ISHIBASHI M, KOGO R, SHIBATA K, et al. Clinical signifi-cance of the expression of long non-coding RNA HOTAIR inprimary hepatocellular carcinoma[J]. Oncol Rep, 2012, 29 (3) :946-950.

[15] TU ZQ, LI RJ, MEI JZ, et al. Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepato-cellular carcinoma[J]. Int J Clin Exp Pathol, 2014, 7 (7) :4303-4309.

[16] ZHENG S, LV Z, ZHOU L, et al. Long non-coding RNAPVT1 is associated with tumor progression and predicts recur-rence in hepatocellular carcinoma patients[J]. Oncol Lett, 2015, 9 (2) :955-963.

[17] TAKAHASHI K, YAN IK, KOGURE T, et al. Extracellular vesi-cle-mediated transfer of long non-coding RNA ROR modu-lates chemosensitivity in human hepatocellular cancer[J].FEBS Open Bio, 2014, 4:458-467.

[18] SONG Y, ZHAO LY, LI YQ, et al. Research progress in epi-thelial-mesenchymal transition in glioma cells and targeted in-hibiting strategies[J]. J Jilin Univ:Med Edit, 2018, 43 (5) :1064-1068. (in Chinese) 宋扬, 赵丽艳, 李蕴潜, 等.胶质瘤细胞上皮-间质转化及靶向抑制策略的研究进展[J].吉林大学学报:医学版, 2018, 43 (5) :1064-1068.

[19] ZHAI B, YAN HX, LIU SQ, et al. Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas[J].World J Gastroenterol, 2008, 14 (37) :5665-5673.

[20] HU YL, SUN DW, LUO FX, et al. Influencing factors for micro-vascular invasion in patients with single hepatocellular carcino-ma and their prognosis[J]. J Clin Hepatol, 2018, 34 (9) :1911-1916. (in Chinese) 胡月雷, 孙大伟, 骆飞翔, 等.单发肝细胞癌发生微血管侵犯的影响因素及预后分析[J].临床肝胆病杂志, 2018, 34 (9) :1911-1916.

[21] XU ZY, DING SM, ZHOU L, et al. FOXC1 contributes to mi-crovascular invasion in primary hepatocellular carcinoma viaregulating epithelial-mesenchymal transition[J]. Int J BiolSci, 2012, 8 (8) :1130-1141.

[22] UCHIBORI K, KASAMATSU A, SUNAGA M, et al. Establish-ment and characterization of two 5-fluorouracil-resistanthepatocellular carcinoma cell lines[J]. Int J Oncol, 2012, 40 (4) :1005-1010.

[23] BAO J, ZHANG J, WANG J. MicroRNA-101 inhibits epithelial-mesenchymal transition in human liver carcinoma MHCC97Hcells via USP22[J]. Ogran Transplantation, 2017, 8 (3) :209-214. (in Chinese) 鲍洁, 张娟, 王晶.微小RNA-101通过USP22抑制人肝癌MHCC97H细胞的上皮-间质转化功能[J].器官移植, 2017, 8 (3) :209-214.

[24] TANIA M, KHAN MA, FU J. Epithelial to mesenchymal transi-tion inducing transcription factors and metastatic cancer[J].Tumor Biol, 2014, 35 (8) :7335-7342.

[25] CAO SW, HUANG JL, CHEN J, et al. Long non-coding RNAUBE2CP3 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma[J]. On-cotarget, 2017, 8 (39) :65370-6538.

[26] ZHANG PF, WANG F, WU J, et al. LncRNA SNHG3 inducesEMT and sorafenib resistance by modulating the miR-128/CD151 pathway in hepatocellular carcinoma[J]. J Cell Physi-ol, 2018, 234 (3) :2788-2794.

[27] YANG J, LI J, LIU B, et al. Long noncoding RNA AK021443promotes cell proliferation and migration by regulating epitheli-al-mesenchymal transition in hepatocellular carcinoma cells[J]. DNA Cell Biology, 2018, 37 (5) :481-490.

[28] KALLURI R, WEINBERG RA. The basics of epithelial-mesen-chymal transition[J]. J Clin Invest, 2015, 119 (6) :1420-1428.

[29] ZEISBERG M, NEILSON EG. Biomarkers for epithelial-mes-enchymal transitions[J]. J Clin Invest, 2009, 119 (6) :1429-1437.

[30] KORPAL M, LEE ES, HU G, et al. The miR-200 family inhib-its epithelial-mesenchymal transition and cancer cell migra-tion by direct targeting of e-cadherin transcriptional repress-ors ZEB1 and ZEB2[J]. J Biol Chem, 2008, 283 (22) :14910-14914.

[31] LI SP, XU HX, YU Y, et al. LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and me-tastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway[J]. Oncotarget, 2016, 7 (27) :42431-42446.

[32] YUAN JH, YANG F, WANG F, et al. A long noncoding RNAactivated by TGF-βpromotes the invasion-metastasis cas-cade in hepatocellular carcinoma[J]. Cancer Cell, 2014, 25 (5) :666-681.

[33] YANG T, HE X, CHEN A, et al. LncRNA HOTAIR contributesto the malignancy of hepatocellular carcinoma by enhancingepithelial-mesenchymal transition via, sponging miR-23b-3p from ZEB1[J]. Gene, 2018, 670:114-122.

[34] LI T, XIE J, SHEN C, et al. Amplification of long noncodingRNA ZFAS1 promotesmetastasis in hepatocellular carcinoma[J]. Cancer Res, 2015, 75 (15) :3181.

[35] CHEN L, YAO H, WANG K, et al. Long non-coding RNAMALAT1 regulates ZEB1 expression by sponging miR-143-3p and promotes hepatocellular carcinoma progression[J]. JCell Biochem, 2017, 118 (12) :4836-4843.

[36] NIETO MA. The snail superfamily of zinc-finger transcriptionfactors[J]. Nat Rev Mol Cell Biol, 2003, 3 (3) :155-166.

[37] BRZOZOWA M, MICHALSKI M, WYROBIEC G, et al. The roleof Snail1 transcription factor in colorectal cancer progressionand metastasis[J]. Contemp Oncol (Pozn) , 2015, 19 (4) :265-270.

[38] XU Y, WANG B, ZHANG F, et al. Long non-coding RNACCAT2 is associated with poor prognosis in hepatocellular car-cinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial-mesenchymal transition[J]. Onco Tar-gets Ther, 2017, 10:1191-1198.

[39] CHEN W, YOU J, ZHENG Q, et al. Downregulation of lncRNAOGFRP1 inhibits hepatocellular carcinoma progression byAKT/m TOR and Wnt/β-catenin signaling pathways[J].Cancer Manag Res, 2018, 10:1817-1826.

[40] FAN H, LV P, MU T, et al. LncRNA n335586/miR-924/CK-MT1A axis contributes to cell migration and invasion in hepato-cellular carcinoma cells[J]. Cancer Lett, 2018, 429:89-99.

[41] ZHANG L, YANG F, YUAN JH, et al. Epigenetic activation ofthe MiR-200 family contributes to H19-mediated metastasissuppression in hepatocellular carcinoma[J]. Carcinogenesis, 2013, 34 (3) :577-586.

[42] WANG Y, LIU Z, YAO B, et al. Long non-coding RNA CASC2suppresses epithelial-mesenchymal transition of hepatocellularcarcinoma cells through CASC2/miR-367/FBXW7 axis[J]. MolCancer, 2017, 16 (1) :123.

[43] JIA M, JIANG L, WANG YD, et al. lincRNA-p21 inhibits in-vasion and metastasis of hepatocellular carcinoma throughNotch signaling-induced epithelial-mesenchymal transition[J]. Hepatol Res, 2016, 46 (11) :1137-1144.

[44] BOVOLENTA P, ESTEVE P, RUIZ JM, et al. Beyond Wnt inhi-bition:New functions of secreted Frizzled-related proteins indevelopment and disease[J]. J Cell Sci, 2008, 121 (Pt 6) :737-746.

[45] LIU F, YUAN JH, HUANG JF, et al. Long noncoding RNAFTX inhibits hepatocellular carcinoma proliferation and metas-tasis by binding MCM2 and miR-374a[J]. Oncogene, 2016, 35 (41) :5422-5434.

[46] LIANG WC, REN JL, WONG CW, et al. LncRNA-NEF antag-onized epithelial to mesenchymal transition and cancer metas-tasis via cis-regulating FOXA2 and inactivating Wnt/β-cate-nin signaling[J]. Oncogene, 2018, 37 (11) :1445-1456.

[47] WANG TH, WU CH, YEH CT, et al. Melatonin suppresseshepatocellular carcinoma progression via lncRNA-CPS1-IT-mediated HIF-1αinactivation[J]. Oncotarget, 2017, 8 (47) :82280-82293.

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