中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

慢性HBV感染者血脂和白蛋白-胆红素指数与疾病进展的关系

曹雯君 王同同 郜玉峰 邹桂舟

引用本文:
Citation:

慢性HBV感染者血脂和白蛋白-胆红素指数与疾病进展的关系

DOI: 10.3969/j.issn.1001-5256.2019.03.014
基金项目: 

安徽省自然科学基金(1608085MH164); 

详细信息
  • 中图分类号: R512.62;R575

Association of blood lipids and albumin-bilirubin index with disease progression in patients with chronic hepatitis B virus infection

Research funding: 

 

  • 摘要: 目的探讨血脂相关指标及白蛋白-胆红素指数(ALBI指数)对慢性HBV感染后疾病进展的评估价值。方法选取2016年6月-2017年6月在安徽医科大学第二附属医院就诊的184例慢性HBV感染者,将其根据不同的疾病阶段分为HBV携带者74例(ASC组),慢性乙型肝炎患者70例(CHB组),代偿期肝硬化患者40例(LC组),并以50例健康对照者作为对照(HC组)。检测血脂相关指标和肝功能指标,分析血脂指标与ALBI指数在慢性HBV感染后疾病进展中的变化特点。计量资料多组间比较采用单因素方差分析,进一步两两比较采用Dunnett法;计数资料组间比较采用χ2检验;相关性分析采用Pearson相关分析法。结果 ASC组、CHB组、LC组、HC组间血脂指标CHO、HDL-C、LDL-C、APOA、APOB差异均有统计学意义(F值分别为12. 075、19. 559、6. 554、9. 392、5. 458,P值均<0. 001);与其他3组比较,LC组以上指标降低最为显著,组间差异均有统计学意义(P值均<0. 05)。ALBI指数在4组间差异有统计学意义(F=49. 225,P <0...

     

  • [1] YANG S, LIN Q, LIN W, et al. Effect of adjuvant interferontherapy on hepatitis B virus-related hepatocellular carcino-ma:A systematic review[J]. World J Surg Oncol, 2016, 14 (1) :159.
    [2] SHI J, SHEN Z, MIAO H, et al. Association between serumlipid levels and antiviral treatment outcome inpatients with chro-nic hepatitis[J]. J Clin Hepatol, 2014, 30 (6) :496-500. (inChinese) 时佳, 沈震, 苗慧, 等.血脂水平与慢性丙型肝炎患者抗病毒疗效的相关性分析[J].临床肝胆病杂志, 2014, 30 (6) :496-500.
    [3] ABBASI A, BHUTTO AR, BUTT N, et al. Serum cholesterol:Could it be a sixth parameter of Child-Pugh scoring system incirrhotics due to viral hepatitis?[J]. J Coll Physicians SurgPak, 2012, 22 (8) :484-487.
    [4] WANG CC, TSENG TC, KAO JH. Hepatitis B virus infectionand metabolic syndrome:Fact or fiction?[J]. J Gastroen-terol Hepatol, 2015, 30 (1) :14-20.
    [5] NAU AL, SOARES JC, SHIOZAWA MB, et al. Clinical and la-boratory characteristics associated with dyslipidemia and liversteatosis in chronic HBV carriers[J]. Rev Soc Bras Med Trop, 2014, 47 (2) :158-164.
    [6] JOHNSON PJ, BERHANE S, KAGEBAYASHI C, et al. As-sessment of liver function in patients with hepatocellular carci-noma:A new evidence-based approach-the ALBI grade[J]. J Clin Oncol, 2015, 33 (6) :550-558.
    [7] BO C, SHA L. Albumin-bilirubin (ALBI) score at admissionpredicts possible outcomes in patients with acute-on-chron-ic liver failure[J]. Medicine, 2017, 96 (24) :e7142.
    [8] Chinese Society of Hepatology and Chinese Society of Infec-tious Diseases, Chinese Medical Association. The guidelinesof prevention and treatment for chronic hepatitis B:A 2015 Up-date[J]. J Clin Hepatol, 2015, 31 (12) :1941-1960. (inChinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1941-1960.
    [9] ZHANG C, GONG L, CHEN Y, et al. A human-derived pro-tein SBP (HBsAg-binding protein) can bind to hepatitis B vi-rus surface antigen (HBs Ag) and enhance the immune re-sponse to hepatitis B virus (HBV) vaccine[J]. Mol Immunol, 2013, 53 (1-2) :60-71.
    [10] VERE CC, NEAGOE D, STREBA CT, et al. Steatosis and ser-um lipid patterns in patients with chronic viral hepatitis:Differ-ences related to viral etiology[J]. Rom J Morphol Embryol, 2010, 51 (3) :509-514.
    [11] ARAIN SQ, TALPUR FN, CHANNA NA, et al. Serum lipids asan indicator for the alteration of liver function in patients withhepatitis B[J]. Lipids Health Dis, 2018, 17 (1) :36.
    [12] WU T, ZHENG X, YANG M, et al. Serum lipid alterations iden-tified in chronic hepatitis B, hepatitis B virus-associated cir-rhosis and carcinoma patients[J]. Sci Rep, 2017, 7:42710.
    [13] GHADIR MR, RIAHIN AA, HAVASPOUR A, et al. The relation-ship between lipid profile and severity of liver damage in cir-rhotic patients[J]. Hepat Mon, 2010, 10 (4) :285-288.
    [14] BASSANI L, FERNANDES SA, RAIMUNDO FV, et al. Lipidprofile of cirrhotic patients and its association with prognosticscores:A cross-sectional study[J]. Arq Gastroenterol, 2015, 52 (3) :210.
    [15] CHEN RC, CAI YJ, WU JM, et al. Usefulness of albumin-biliru-bin grade for evaluation of long-term prognosis for hepatitis B-related cirrhosis[J]. J Viral Hepat, 2017, 24 (13) :238-245.
  • 加载中
计量
  • 文章访问数:  1285
  • HTML全文浏览量:  21
  • PDF下载量:  317
  • 被引次数: 0
出版历程
  • 收稿日期:  2018-10-09
  • 出版日期:  2019-03-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回