胆汁淤积动物模型的构建及应用前景

杜丽娜; 杨燕

doi:10.3969/j.issn.1001-5256.2019.02.046

胆汁淤积动物模型的构建及应用前景

DOI: 10.3969/j.issn.1001-5256.2019.02.046

杜丽娜,
杨燕

国家儿童医学中心/首都医科大学附属北京儿童医院中医科

基金项目:

国家自然科学基金面上项目(81473725)；

详细信息

中图分类号: R575;R-332
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出版历程
- 收稿日期: 2018-10-08
- 出版日期: 2019-02-20

Establishment and application of animal models of cholestasis

Du LiNa,
Yang Yan

Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University/National Center for Children's Health

Research funding:

摘要

摘要: 胆汁淤积性肝病是1岁以内儿童常见病之一,其病因复杂,预后不一,为进一步深入研究其发病机制及治疗策略,研究者建立了多种不同的胆汁淤积动物模型。如通过手术或外界物理化学损伤建立梗阻型胆汁淤积模型;通过化学药品或内毒素诱导建立肝内胆汁淤积模型,包括α-萘异硫氰酸酯、脂多糖、3,5-二乙氧基羰基-1,4-二氢三甲基吡啶、雌激素、氯丙嗪、利福平、石胆酸等;或通过肠道损伤与肠外营养相结合建立肠外营养相关胆汁淤积模型。各类模型体现了不同的病因和发展过程。现对医学研究中较常用的胆汁淤积动物模型特点及机理、适应证作一综述。
- 胆汁淤积 /
- 模型,动物 /
- 综述
Abstract: Cholestatic liver disease is one of the common diseases in children aged < 1 year and has a complex etiology and different outcomes. Various animal models have been established to further investigate the pathogenesis of cholestatic liver disease and related treatment strategies. A model of obstructive cholestasis is established by surgery or external physical and chemical damage; a model of intrahepatic cholestasis is induced by chemicals or endotoxins, including α-naphthyl isothiocyanate, lipopolysaccharide, 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine, estrogen, chlorpromazine, rifampicin, and lithocholic acid; a model of parenteral nutrition-associated cholestasis is established by a combination of intestinal damage and parenteral nutrition. These models reflect different causes and development processes.This article reviews the characteristics, mechanisms, and indications of animal models of cholestasis commonly used in medical research.
- cholestasis /
- models, animal /
- review

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参考文献(29)

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