IL-8与自身免疫性肝病的关系

雷云洁; 杨晋辉

doi:10.3969/j.issn.1001-5256.2019.02.039

IL-8与自身免疫性肝病的关系

DOI: 10.3969/j.issn.1001-5256.2019.02.039

昆明医科大学第二附属医院消化内科

基金项目:

国家自然科学基金(81660102)；昆明医科大学研究生创新基金(2018S121)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2018-09-17
- 出版日期: 2019-02-20

The association between interleukin-8 and autoimmune liver diseases

Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University

Research funding:

摘要

摘要: IL-8是一种具有趋化作用的炎性细胞因子,在自身免疫性肝病中的表达水平明显升高,且能够与其相应受体——趋化因子受体1、趋化因子受体2结合,进而发挥促炎性细胞趋化、促血管生成、促纤维化和诱导细胞增殖的作用,参与疾病进程。综述了IL-8与自身免疫性肝病的相关研究进展。
- 白细胞介素8 /
- 肝炎,自身免疫性 /
- 原发性胆汁性胆管炎 /
- 原发性硬化性胆管炎 /
- 综述
Abstract: Interleukin-8 ( IL-8) is an inflammatory cytokine with chemotaxis and there is a significant increase in the expression of IL-8 in autoimmune liver diseases. It participates in disease progression by binding to its receptors CXCR1 and CXCR2, promoting chemotaxis of inflammatory cells, angiogenesis, and fibrosis, and inducing cell proliferation. This article reviews the research advances in the association between IL-8 and autoimmune liver diseases.
- interleukin-8 /
- hepatitis, autoimmune /
- primary biliary cholangitis /
- primary sclerosing cholangitis /
- review

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参考文献(30)

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