HBV pgRNA在慢性乙型肝炎进程中的可能意义

谭宁; 罗皓; 徐小元

doi:10.3969/j.issn.1001-5256.2018.10.035

HBV pgRNA在慢性乙型肝炎进程中的可能意义

DOI: 10.3969/j.issn.1001-5256.2018.10.035

北京大学第一医院感染疾病科

基金项目:

传染病国家科技重大专项(2017ZX10302201-004-009)；北京市科技计划项目(D161100002716003;D161100002716002; D171100003117005)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2018-05-28
- 出版日期: 2018-10-20

Significance of hepatitis B virus pregenomic RNA in the progression of chronic hepatitis B

Department of Infectious Diseases, Peking University First Hospital

Research funding:

摘要

摘要: HBV pgRNA是HBV cccDNA的直接转录产物,能够通过反映HBV cccDNA的转录活动状态进而反映慢性乙型肝炎病情进展,指导临床治疗和判断预后。与其他常用HBV感染血清标志物相比,HBV pgRNA在反映HBV复制活动和抗病毒治疗效果等方面更灵敏,对于抗病毒治疗阶段终点有预测价值。通过综合HBV pgRNA与HBcrAg、HBV cccDNA的相关性来阐述HBV pgRNA在反映慢性乙型肝炎治疗过程中病情变化的可能意义。
- 肝炎,乙型,慢性 /
- HBV pgRNA /
- HBcrAg /
- 综述
Abstract: Hepatitis B virus ( HBV) pregenomic RNA ( pgRNA) is the direct transcription product of HBV covalently closed circular DNA ( cccDNA) and can reflect the transcriptional activity of HBV cccDNA and the progression of chronic hepatitis B, which provides guidance for clinical treatment and prognostic prediction. Compared with other common serological markers for HBV infection, HBV pgRNA is more sensitive in reflecting HBV replication and the effect of antiviral therapy has a certain predictive value for endpoints in the stages of antiviral therapy. This article elaborates on the significance of HBV pgRNA in reflecting the changes in disease conditions with reference to the correlation of HBV pgRNA with HBcrAg and HBV cccDNA.
- hepatitis B, chronic /
- HBV pregenomic RNA /
- hepatitis B core-related antigen /
- review

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参考文献(29)

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