自噬在HBV及相关肝脏疾病中的双重作用

彭佳丽; 赖欣; 韦嘉

doi:10.3969/j.issn.1001-5256.2018.10.034

自噬在HBV及相关肝脏疾病中的双重作用

DOI: 10.3969/j.issn.1001-5256.2018.10.034

昆明医科大学第四附属医院肝病科

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2018-04-28
- 出版日期: 2018-10-20

Dual role of autophagy in hepatitis B virus and related liver diseases

Department of Hepatology, The Fourth Affiliated Hospital of Kunming Medical University

摘要

摘要: 自噬是一种溶酶体降解过程,其在疾病的发生发展中具有双重作用,即自噬促进细胞存活,又可诱导细胞死亡。简述了自噬在HBV、慢性乙型肝炎、肝纤维化及肝细胞癌中的双重作用,以及自噬在相关肝脏疾病中的作用机制。提出了细胞自噬可能是未来HBV相关肝病治疗的研究方向,为肝纤维化和肝细胞癌的治疗提供了新思路。
- 自噬 /
- 肝炎病毒,乙型 /
- 肝炎,乙型,慢性 /
- 肝硬化 /
- 癌,肝细胞 /
- 综述
Abstract: Autophagy is a process of lysosome degradation and has a dual role in the development and progression of diseases, i. e., it can promote cell survival and induce cell death. This article introduces the dual role of autophagy in hepatitis B virus ( HBV) , chronic hepatitis B, liver fibrosis, and hepatocellular carcinoma and the mechanism of action of autophagy in related liver diseases. It is pointed out that autophagy may be a future research direction for the treatment of HBV-related liver diseases and can provide new ideas for the treatment of liver fibrosis and hepatocellular carcinoma.
- autophagy /
- hepatitis B virus /
- hepatitis B, chronic /
- liver cirrhosis /
- carcinoma, hepatocellular /
- review

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