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健脾化湿止血方对肝硬化食管胃底静脉曲张破裂出血患者1年内再出血的影响

侯艺鑫 张群 杨志云 杨玉英 江宇泳 王宪波

引用本文:
Citation:

健脾化湿止血方对肝硬化食管胃底静脉曲张破裂出血患者1年内再出血的影响

DOI: 10.3969/j.issn.1001-5256.2018.10.015
基金项目: 

国家自然科学基金(81774234,81473641); 首都医科大学附属北京地坛医院院内桥梁计划(DTQL201602); 北京市科学技术委员会“首都临床特色应用研究”资助项目(Z181100001718052); 

详细信息
  • 中图分类号: R259

Effect of spleen-strengthening, dampness-removing, and hemostatic prescription on rebleeding within one year in cirrhotic patients with esophagogastric variceal bleeding

Research funding: 

 

  • 摘要: 目的探讨健脾化湿止血方对肝硬化食管胃底静脉曲张破裂出血(EGVB)患者1年内发生再出血的影响。方法选取2008年8月-2016年10首都医科大学附属北京地坛医院收治的肝硬化EGVB患者750例,随访1年。根据累计日剂量(cDDD)将随访期内应用健脾化湿止血方中药剂量≥28 cDDD的患者纳入中药组(n=276),而服用中药<28 cDDD的患者被纳入非中药组(n=474)。正态分布的计量资料两组间比较采用t检验;非正态分布的计量资料两组间比较采用Mann-Whitney U检验。计数资料两组间比较采用χ2检验。采用多因素logistic回归分析EGVB再出血的影响因素。结果是否服用健脾化湿止血方是影响肝硬化EGVB患者1年内发生再出血的独立危险因素之一(比值比=0. 076,95%可信区间:0. 0390. 126,P=0. 002)。中药组患者1年内再出血发生率显著低于非中药组(43. 5%vs 55. 1%,χ2=4. 246,P=0. 025)。中药组患者自随访至发生再出血的中位时间为95 d,非中药组为121 d,两组比较差异有统计学意义(Z=1. ...

     

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