Imaging-guided multimode tumor ablation therapy system for malignant hepatic tumors is a therapeutic technique, the performance of which is guided by medical imaging technology, and in the process of alternate conversion between cryoablation and thermal ablation, through accurate control of lesion area temperature and quantitative planning of ablation process, the in situ tumor cells and their circulatory system are thoroughly destroyed, and the active tumor antigens are simultaneously released at a maximum extent, thereby controlling the recurrence and metastasis of malignant hepatic tumors. In order to standardize the operative technique of multimode ablation therapy for malignant hepatic tumors, to enable hospitals at different levels have the ability to carry out the implementation of this therapy and to ensure medical safety and clinical efficacy, the Society of Interventional Therapy of China Anti-cancer Association and the Solid Tumor Theranostics Committee of Shanghai Anti-cancer Association have together organized domestic experts of multiple disciplines, who have been involved in the field of oncotherapy, to make a professional and serious discussion on the subject of“imaging-guided multimode tumor ablation therapy system for malignant hepatic tumors”, focusing on its indications, contraindications and techniques, and the final expert consensus is presented here.