中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

门静脉系统血栓的发生发展机制

羊媛苑 王晓艳

引用本文:
Citation:

门静脉系统血栓的发生发展机制

DOI: 10.3969/j.issn.1001-5256.2018.10.005
详细信息
  • 中图分类号: R575.2

Mechanisms of the development and progression of portal vein thrombosis

  • 摘要: 门静脉系统血栓(PVT)指门静脉或其分支血管内形成血栓,可导致门静脉高压,引起一系列病理生理变化。PVT通常是由多种病因引起的,主要包括血液高凝状态、门静脉流速降低和血管内皮损伤等。主要探讨了PVT的发病机制,指出临床上应对PVT患者的病因进行全面评估,以协助治疗。

     

  • [1]OGREN M, BERGQVIST D, BJORCK M, et al.Portal vein thrombosis:prevalence, patient characteristics and lifetime risk:A population study based on 23, 796 consecutive autopsies[J].World JGastroenterol, 2006, 12 (13) :2115-2119.
    [2]OKUDA K, OHNISHI K, KIMURA K, et al.Incidence of portal vein thrombosis in liver cirrhosis.An angiographic study in 708 patients[J].Gastroenterology, 1985, 89 (2) :279-286.
    [3]JAMIESON NV.Changing perspectives in portal vein thrombosis and liver transplantation[J].Transplantation, 2000, 69 (9) :1772-1774.
    [4]YERDEL MA, GUNSON B, MIRZA D, et al.Portal vein thrombosis in adults undergoing liver transplantation:Risk factors, screening, management, and outcome[J].Transplantation, 2000, 69 (9) :1873-1881.
    [5]HENDERSON JM, GILMORE GT, MACKAY GJ, et al.Hemodynamics during liver transplantation:The interactions between cardiac output and portal venous and hepatic arterial flows[J].Hepatology, 1992, 16 (3) :715-718.
    [6]DE GAETANO AM, LAFORTUNE M, PATRIQUIN H, et al.Cavernous transformation of the portal vein:Patterns of intrahepatic and splanchnic collateral circulation detected with Doppler sonography[J].AJR Am J Roentgenol, 1995, 165 (5) :1151-1155.
    [7]KUMAR A, SHARMA P, ARORA A.Review article:Portal vein obstruction-epidemiology, pathogenesis, natural history, prognosis and treatment[J].Aliment Pharmacol Ther, 2015, 41 (3) :276-292.
    [8]D'AMICO M, SAMMARCO P, PASTA L.Thrombophilic genetic factors PAI-1, MTHFRC677T, V Leiden 506Q, and prothrombin20210A in noncirrhotic portal vein thrombosis and budd-chiari syndrome in a caucasian population[J].Int J Vasc Med, 2013, 2013:717480.
    [9]de BRUIJNE EL, DARWISH MURAD S, de MAAT MP, et al.Genetic variation in thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with the risk of splanchnic vein thrombosis[J].Thromb Haemost, 2007, 97 (2) :181-185.
    [10]MARTINELLI I, PRIMIGNANI M, AGHEMO A, et al.High levels of factor VIII and risk of extra-hepatic portal vein obstruction[J].J Hepatol, 2009, 50 (5) :916-922.
    [11]QI X, REN W, DE STEFANO V, et al.Associations of coagulation factor V Leiden and prothrombin G20210A mutations with BuddChiari syndrome and portal vein thrombosis:A systematic review and meta-analysis[J].Clin Gastroenterol Hepatol, 2014, 12 (11) :1801-1812, e1807.
    [12]NERY F, CHEVRET S, CONDAT B, et al.Causes and consequences of portal vein thrombosis in 1, 243 patients with cirrhosis:results of a longitudinal study[J].Hepatology, 2015, 61 (2) :660-667.
    [13]QI X, WU F, HE C, et al.Thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis:an observational study with a systematic review of the literature[J].Eur J Gastroenterol Hepatol, 2015, 27 (1) :77-83.
    [14]QI X, DE STEFANO V, WANG J, et al.Prevalence of inherited antithrombin, protein C, and protein S deficiencies in portal vein system thrombosis and Budd-Chiari syndrome:A systematic review and meta-analysis of observational studies[J].J Gastroenterol Hepatol, 2013, 28 (3) :432-442.
    [15]AMITRANO L, BRANCACCIO V, GUARDASCIONE MA, et al.Portal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients:Role of genetic thrombophilia[J].Endoscopy, 2002, 34 (7) :535-538.
    [16]WALKER AP.Portal vein thrombosis:What is the role of genetics?[J].Eur J Gastroenterol Hepatol, 2005, 17 (7) :705-707.
    [17]ERKAN O, BOZDAYI AM, DISIBEYAZ S, et al.Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis[J].Eur J Gastroenterol Hepatol, 2005, 17 (3) :339-343.
    [18]VIOLI F, FERRO D, SALIOLA M, et al.Evaluation of D-dimer in patients with liver cirrhosis[J].Thromb Haemost, 1989, 62 (4) :1149-1150.
    [19]CHAWLA Y, DUSEJA A, DHIMAN RK.Review article:the modern management of portal vein thrombosis[J].Aliment Pharmacol Ther, 2009, 30 (9) :881-894.
    [20]TEFFERI A, THIELE J, ORAZI A, et al.Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis:Recommendations from an ad hoc international expert panel[J].Blood, 2007, 110 (4) :1092-1097.
    [21]QI X, ZHANG C, HAN G, et al.Prevalence of the JAK2V617F mutation in Chinese patients with Budd-Chiari syndrome and portal vein thrombosis:a prospective study[J].J Gastroenterol Hepatol, 2012, 27 (6) :1036-1043.
    [22]DEEPAK A, PUNAMIYA S, PATEL N, et al.Prevalence of JAK29V617F mutation in intra-abdominal venous thrombosis[J].Trop Gastroenterol, 2011, 32 (4) :279-284.
    [23]KLAMPFL T, GISSLINGER H, HARUTYUNYAN AS, et al.Somatic mutations of calreticulin in myeloproliferative neoplasms[J].N Engl JMed, 2013, 369 (25) :2379-2390.
    [24]NANGALIA J, MASSIE CE, BAXTER EJ, et al.Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2[J].N Engl J Med, 2013, 369 (25) :2391-2405.
    [25]LI M, de STEFANO V, SONG T, et al.Prevalence of CALR mutations in splanchnic vein thrombosis:A systematic review and meta-analysis[J].Thromb Res, 2018, 167:96-103.
    [26]ZIAKAS PD, POULOU LS, ROKAS GI, et al.Thrombosis in paroxysmal nocturnal hemoglobinuria:Sites, risks, outcome.An overview[J].J Thromb Haemost, 2007, 5 (3) :642-645.
    [27]QI X, HE C, HAN G, et al.Prevalence of paroxysmal nocturnal hemoglobinuria in Chinese patients with Budd-Chiari syndrome or portal vein thrombosis[J].J Gastroenterol Hepatol, 2013, 28 (1) :148-152.
    [28]AGENO W, DENTALI F, de STEFANO V, et al.Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria phenotype in patients with splanchnic vein thrombosis[J].Thromb Res, 2014, 133 (6) :1052-1055.
    [29]QI X, de STEFANO V, SU C, et al.Associations of antiphospholipid antibodies with splanchnic vein thrombosis:A systematic review with meta-analysis[J].Medicine (Baltimore) , 2015, 94 (4) :e496.
    [30]QI X, YANG Z, de STEFANO V, et al.Methylenetetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia in Budd-Chiari syndrome and portal vein thrombosis:A systematic review and meta-analysis of observational studies[J].Hepatol Res, 2014, 44 (14) :e480-e498.
    [31]NI YH, WANG NC, PENG MY, et al.Bacteroides fragilis bacteremia associated with portal vein and superior mesentery vein thrombosis secondary to antithrombin III and protein C deficiency:a case report[J].JMicrobiol Immunol Infect, 2002, 35 (4) :255-258.
    [32]BUREAU C, LAURENT J, ROBIC MA, et al.Central obesity is associated with non-cirrhotic portal vein thrombosis[J].J Hepatol, 2016, 64 (2) :427-432.
    [33]ZAKKO A, T KRONER P, NANKANI R, et al.Obesity is not associated with an increased risk of portal vein thrombosis in cirrhotic patients[J].Gastroenterol Hepatol Bed Bench, 2018, 11 (2) :153-158.
    [34]BASTARD JP, PIERONI L.Plasma plasminogen activator inhibitor1, insulin resistance and android obesity[J].Biomed Pharmacother, 1999, 53 (10) :455-461.
    [35]SCHAFER K, KONSTANTINIDES S.Mechanisms linking leptin to arterial and venous thrombosis:Potential pharmacological targets[J].Curr Pharm Des, 2014, 20 (4) :635-640.
    [36]ZIRONI G, GAIANI S, FENYVES D, et al.Value of measurement of mean portal flow velocity by Doppler flowmetry in the diagnosis of portal hypertension[J].J Hepatol, 1992, 16 (3) :298-303.
    [37]ZOCCO MA, DI STASIO E, de CRISTOFARO R, et al.Thrombotic risk factors in patients with liver cirrhosis:correlation with MELD scoring system and portal vein thrombosis development[J].J Hepatol, 2009, 51 (4) :682-689.
    [38]ZOLI M, IERVESE T, MERKEL C, et al.Prognostic significance of portal hemodynamics in patients with compensated cirrhosis[J].J Hepatol, 1993, 17 (1) :56-61.
    [39]QI XS, BAI M, FAN DM.Nonselective beta-blockers may induce development of portal vein thrombosis in cirrhosis[J].World J Gastroenterol, 2014, 20 (32) :11463-11466.
    [40]ZAMPINO R, LEBANO R, COPPOLA N, et al.The use of nonselective beta blockers is a risk factor for portal vein thrombosis in cirrhotic patients[J].Saudi J Gastroenterol, 2018, 24 (1) :25-29.
    [41]PLESSIER A, DARWISH-MURAD S, HERNANDEZ-GUERRA M, et al.Acute portal vein thrombosis unrelated to cirrhosis:A prospective multicenter follow-up study[J].Hepatology, 2010, 51 (1) :210-218.
    [42]DORFFEL T, WRUCK T, RUCKERT RI, et al.Vascular complications in acute pancreatitis assessed by color duplex ultrasonography[J].Pancreas, 2000, 21 (2) :126-133.
    [43]ZHENG RQ, KUDO M, INUI K, et al.Transient portal vein thrombosis caused by radiofrequency ablation for hepatocellular carcinoma[J].J Gastroenterol, 2003, 38 (1) :101-103.
    [44]HABU D, NISHIGUCHI S, SHIOMI S, et al.Portal vein thrombosis following percutaneous ethanol injection therapy for hepatocellular carcinoma[J].Indian J Gastroenterol, 2002, 21 (4) :162-163.
    [45]MATSUMOTO K, YAMAO K, OHASHI K, et al.Acute portal vein thrombosis after EUS-guided FNA of pancreatic cancer:Case report[J].Gastrointest Endosc, 2003, 57 (2) :269-271.
    [46]VALI T, TEIN A, TIGANIK V, et al.Vascular complications after orthotopic liver transplantation in Estonia[J].Transplant Proc, 2013, 45 (3) :1201-1203.
    [47]MOHAN N, KARKRA S, RASTOGI A, et al.Outcome of 200 pediatric living donor liver transplantations in India[J].Indian Pediatr, 2017, 54 (11) :913-918.
    [48]JAIN M, JAIN J, PASSI GR, et al.Profile of extrahepatic portal venous obstruction among children in Central India[J].Clin Exp Hepatol, 2017, 3 (4) :209-211.
  • 加载中
计量
  • 文章访问数:  1945
  • HTML全文浏览量:  49
  • PDF下载量:  435
  • 被引次数: 0
出版历程
  • 出版日期:  2018-10-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回