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经肝动脉化疗栓塞术联合射频消融治疗巨大肝细胞癌1例报告

刘博智 袁筑慧 李威

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经肝动脉化疗栓塞术联合射频消融治疗巨大肝细胞癌1例报告

DOI: 10.3969/j.issn.1001-5256.2018.07.031
详细信息
  • 中图分类号: R735.7

A case of large hepatocellular carcinoma treated by transcatheter arterial chemoembolization combined with radiofrequency ablation

  • 摘要: <正>原发性肝癌是我国发病率第4位的恶性肿瘤,也是第3位肿瘤致死病因[1]。肝细胞癌(以下简称肝癌)占原发性肝癌的85%~90%。在我国,肝炎病毒感染是导致肝癌的重要病因之一,以HBV为主[2]。HBV相关肝癌的临床特征是患病早期肝功能代偿良好,无明显不适,但发现病变时肿瘤的直径多大于其他病毒导致的肝癌[3],因此在我国肝癌患者中,巨大肝癌(直径≥10 cm)常见。对于巨大肝癌,临床上常用的治疗手段有手术切除和多次经肝动脉化疗栓塞术(TACE),但治疗效果均不理

     

  • [1]National Health and Family Planning Commission of the People's Republic of China.Diagnosis, management, and treatment of hepatocellular carcinoma (V2017) [J].J Clin Hepatol, 2017, 33 (8) :1419-1431. (in Chinese) 中华人民共和国国家卫生和计划生育委员会.原发性肝癌诊疗规范 (2017年版) [J].临床肝胆病杂志, 2017, 33 (8) :1419-1431.
    [2]GUO TZ, HAN LX, LUO Y, et al.Risk factors of liver cancer in patients with hepatitis B virus infection[J].Int J Virol, 2016, 23 (1) :26-28. (in Chinese) 郭铁志, 韩立新, 罗研, 等.乙型肝炎病毒感染患者肝癌发病的影响因素研究[J].国际病毒学杂志, 2016, 23 (1) :26-28.
    [3]CHEN CH, HUANG GT, YANG PM, et al.Hepatitis B-and C-related hepatocellular carcinomas yield different clinical features and prognosis[J].Eur J Cancer, 2006, 42 (15) :2524-2529.
    [4]LIU FB, GENG XP.Choice of surgical treatment of large hepatocellular carcinoma[J].J Hepatobiliary Surg, 2017, 25 (1) :1-4. (in Chinese) 刘付宝, 耿小平.巨大肝癌外科手术治疗的抉择[J].肝胆外科杂志, 2017, 25 (1) :1-4.
    [5]Ministry of Health of the People's Republic of China.Diagnosis, management, and treatment of hepatocellular carcinoma (V2011) [J].J Clin Hepatol, 2011, 27 (11) :1141-1159. (in Chinese) 中华人民共和国卫生部.原发性肝癌诊疗规范 (2011年版) [J].临床肝胆病杂志, 2011, 27 (11) :1141-1159.
    [6]ZHENG JS, LONG J, SUN B, et al.Transcatheter arterial chemoembolization combined with radiofrequency ablation can improve survival of patients with hepatocellular carcinoma with portal vein tumour thrombosis:Extending the indication for ablation?[J].Clin Radiol, 2014, 69 (6) :e253-e263.
    [7]LI Z, ZHU JY.An interpretation of diagnosis, management, and treatment of hepatocellular carcinoma (V2017) [J].J Clin Hepatol, 2017, 33 (9) :1655-1657. (in Chinese) 李照, 朱继业.《原发性肝癌诊疗规范 (2017年版) 》解读[J].临床肝胆病杂志, 2017, 33 (9) :1655-1657.
    [8]National Comprehensive Cancer Network.The NCCN Clinical Practice Guidelines in Oncology (version 3.2017) [EB/OL].[2017-08-15].www.nccn.org/professionals/physician_gls/pdf/hepatobiliary.pdf
    [9]ZHU SL, ZHONG JH, KE Y, et al.Efficacy of hepatic resection vs transarterial chemoembolization for solitary huge hepatocellular carcinoma[J].World J Gastroenterol, 2015, 21 (32) :9630-9637.
    [10]GAO F, GU YK, FAN WJ, et al.Evaluation of transarterial chemoembolization combined with percutaneous ethanol ablation for large hepatocellular carcinoma[J].World J Gastroenterol, 2011, 17 (26) :3145-3150.
    [11]SHRAGER B, JIBARA GA, TABRIZIAN P, et al.Resection of large hepatocellular carcinoma (≥10 cm) :A unique western perspective[J].J Surg Oncol, 2013, 107 (2) :111-117.
    [12]KIM KH, KIM MS, CHANG JS, et al.Therapeutic benefit of radiotherapy in huge (≥10 cm) unresectable hepatocellular carcinoma[J].Liver Int, 2014, 34 (5) :784-794.
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  • 出版日期:  2018-07-20
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