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利用GEO数据库分析肝细胞癌组织中着丝粒蛋白F基因的表达及其与预后的相关性

樊斌 张勇 李锦貌 刘涛 张家耀

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利用GEO数据库分析肝细胞癌组织中着丝粒蛋白F基因的表达及其与预后的相关性

DOI: 10.3969/j.issn.1001-5256.2018.07.022
详细信息
  • 中图分类号: R735.7

Association between the expression of centromere protein F and prognosis in patients with hepatocellular carcinoma:An analysis using GEO database

  • 摘要: 目的探讨着丝粒蛋白F(CENPF)基因在肝细胞癌(HCC)患者组织中的表达情况及与临床特征和预后的相关性。方法利用在线工具Oncomine分析CENPF在HCC与正常肝组织的表达情况,从美国国立生物技术信息中心的GEO数据库下载相关芯片数据(GSE14520),收集215例HCC组织的基因表达谱及相关临床数据,将其分为CENPF低表达组(n=107)和CENPF高表达组(n=108)。对样本中的CENPF基因表达数据及其对应的临床信息进行分析。计量资料组间比较采用t检验;计数资料组间比较采用χ2检验;生存分析采用log-rank(Mantel-Cox)检验;生存资料单因素及多因素分析采用Cox比例风险模型。结果数据集证实HCC组织中CENPF表达水平明显高于正常肝组织(t=12.217,P<0.001)。CENPF基因表达水平与AFP水平、肿瘤大小、TNM分期、转移风险有关系(χ2值分别为6.463、4.338、7.951、17.331,P值均<0.05)。生存分析显示CENPF高表达患者预后明显差于CENPF低表达组(风险比=1...

     

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  • 收稿日期:  2018-01-11
  • 出版日期:  2018-07-20
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