不可忽视的中草药引起的药物性肝损伤

陈军

doi:10.3969/j.issn.1001-5256.2018.06.006

不可忽视的中草药引起的药物性肝损伤

DOI: 10.3969/j.issn.1001-5256.2018.06.006

陈军

中南大学湘雅二医院

详细信息

中图分类号: R575
计量
- 文章访问数: 2081
- HTML全文浏览量: 27
- PDF下载量: 530
- 被引次数: 0
出版历程
- 收稿日期: 2018-04-10
- 出版日期: 2018-06-20

Drug-induced liver injury caused by Chinese herbal medicine cannot be neglected

Chen Jun

The Second Xiangya Hospital of Central South University

摘要

摘要: 中草药的肝毒性是目前受到广泛关注的问题。传统上认为中草药无毒无害的观点值得深思,部分研究结果提示,由于中草药的滥用,包括相当多无资质的"医生"出具的处方导致的中草药肝损伤发病率居高不下。就常见致肝损伤的中药,中药肝损伤的病理类型以及临床特点等作一概述,探讨中草药致肝损伤的可能原因。建议加强中医药的处方管理,防止中药被滥用,中草药所致的肝脏损伤理应得到足够的重视。
- 药物性肝损伤 /
- 中草药
Abstract: The hepatotoxicity of Chinese herbal medicine has attracted more and more attention in recent years. The traditional view that Chinese herbs are poisonless and harmless is worth considering. According to related research findings, liver injury due to the abuse of Chinese herbs caused by prescriptions from unqualified physicians is high retention. This paper summarizes the common Chinese medicine causing liver injury, the pathologic types and clinical characteristics of liver injury induced by Chinese medicine, to explore the possible causes of liver injury induced by Chinese herbs. It is recommended to strengthen the management of traditional Chinese medicine prescriptions and prevent the abuse of Chinese materia medica. Liver injury induced by Chinese herbs should be taken seriously.
- drug induced liver injury /
- drugs, Chinese herbal

HTML全文

参考文献(10)

[1]FONTANA RJ, SEEFF LB, ANDRADE RJ, et al.Standardization of nomenclature and causality assessment of drug-induced liver injury:Summary of a clinical research workshop[J].Hepatology, 2010, 52 (2) :730-742.

[2]SUK KT, KIM DJ, KIM CH, et al.A prospective nationwide study of drug-induced liver injury in Korea[J].Am J Gastroenterol, 2012, 107 (9) :1380-1387.

[3]LAI RT, WANG H, GUI HL, et al.Clinical and pathological features in 138 cases of drug-induced liver injury[J].Chin J Hepatol, 2012, 20 (3) :185-189. (in Chinese) 赖荣陶, 王晖, 桂红莲, 等.138例药物性肝损伤患者的临床特征及肝脏组织学改变[J].中华肝脏病杂志, 2012, 20 (3) :185-189.

[4]OU P, CHEN Y, LI B, et al.Causes, clinical features and outcomes of drug-induced liver injury in hospitalized patients in a Chinese tertiary care hospital[J].Springfield, 2015, 4:802.

[5]YAO YJ, XIAO L, YANG CX, et al.Clinical and pathological features of patients with Chinese herbal drug-induced liver injury[J].J Pract Hepatol, 2016, 19 (4) :441-444. (in Chinese) 姚云洁, 肖朗, 杨才兴, 等.中草药所致DILI患者临床和肝组织病理学特点分析[J].实用肝脏病杂志, 2016, 19 (4) :441-444.

[6]CHEN CW.Pathogenesis, diagnosis and treatment of drug-induced liver disease[J].Chin Hepatol, 2007, 12 (4) :297-302. (in Chinese) 陈成伟.药物性肝病的发病机制及诊治[J].肝脏, 2007, 12 (4) :297-302.

[7]ZHU Y, LI YG, WANG Y, et al.Analysis of clinical characteristics in 595 patients with herb-induced liver injury[J].Chin J Integr Tradit West Med, 2016, 36 (1) :44-48. (in Chinese) 朱云, 李永纲, 王葽, 等.595例中药导致肝损伤临床特征分析[J].中国中西医结合杂志, 2016, 36 (1) :44-48.

[8]MELCHART D, HAGER S, ALBRECHT S, et al.Herbal Traditional Chinese Medicine and suspected liver injury:A prospective study[J].World J Hepatol, 2017, 9 (29) :1141-1157.

[9]Navarro VJ, Barnhart H, Bonkovsky HL, et al.Liver injury from herbals and dietary supplements in the U.S.Drug-Induced Liver Injury Network[J].Hepatology, 2014, 60 (4) :1399-1408.

[10]ZHU Y, NIU M, CHEN J, et al.Hepatobiliary and pancreatic:Comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients[J].J Gastroenterol Hepatol, 2016, 31 (8) :1476-1482.

施引文献

资源附件(0)

访问统计